Skip to content

Publications

Prediagnostic selenium status, selenoprotein gene variants and association with breast cancer risk in a European cohort study

Hughes DJ, Schomburg L, Jenab M, Biessy C, Méplan C, Moskal A, Sun Q, Demircan K, Fedirko V, Weiderpass E, Mukhtar M, Olsen A, Tjønneland A, Overvad K, Schulze M, Nøst TH, Skeie G, Olsen KS, Ricceri F, Grioni S, Palli D, Masala G, Tumino R, Pasanisi F, Amiano P, Colorado Yohar SM, Agudo A,
Sánchez MJ, Ardanaz E, Sund M, Andersson A, Perez-Cornago A, Travis R, Heath AK, Dossus L. 

Free Radic Biol Med 2023 Nov 1:S0891-5849(23)01073-0. doi: 10.1016/j.freeradbiomed.2023.10.401. PMID: 37923090.

________________________________________________________________________________________________________________

Evaluation of human papillomavirus DNA in colorectal cancer and adjacent mucosal tissue samples

Galati L, Gupta P, Tufaro A, Marinaro M, Saponaro C, Escobar Marcillo DI, Loisi D, Sen R, Robitaille A, Brancaccio RN, Cuenin C, McKay-Chopin S, Paradiso AV, Liška V, Souček P, Zito FA, Hughes DJ, Tommasino M, Gheit T.

Infect Agent Cancer. 2023 Nov 8;18(1):71. doi: 10.1186/s13027-023-00552-5. PMID: 37941001.

________________________________________________________________________________________________________________

Involving patients in healthcare research is well documented but can it work in lab-based research?

Connor, A. E., C. Hughes, L. Schäfer, L. McNally, D. O. Raw, K. Bahramian, B. Carr, I. H. Dunne, J. Lysaght, S. A. O. Toole, J. C. Simpson and A. S. Perry

Res Involv Engagem. 2023 Oct 12;9(1):90. doi: 10.1186/s40900-023-00500-y. PMID: 37821914 PMCID: PMC10568930

________________________________________________________________________________________________________________

Cannabidiol Inhibits the Proliferation and Invasiveness of Prostate Cancer Cells

O’Reilly E, Khalifa K, Cosgrave J, Azam H, Prencipe M, Simpson JC, Gallagher WM, Perry AS.

Journal of Natural Products. 2023;86(9):2151-2161. doi:10.1021/acs.jnatprod.3c00363. PMID: 37703852

________________________________________________________________________________________________________________

Association of Antibody Responses to Fusobacterium nucleatum and Streptococcus gallolyticus Proteins with Colorectal Adenoma and Colorectal Cancer

Genua F, Butt J, Waterboer T, Hughes DJ.

Dig Dis Sci. 2023 Aug;68(8):3300-3311. doi: 10.1007/s10620-023-08001-4. Epub 2023 Jun 20. PMID: 37338617.

________________________________________________________________________________________________________________

SRF inhibitors reduce prostate cancer cell proliferation through cell cycle arrest in an isogenic model of castrate-resistant prostate cancer

Azam H, Maher S, Clarke S, Gallagher WM, Prencipe M.

Cell Cycle. 2023 Jul-Aug; 22(14-16):1759-1776. doi: 10.1080/15384101.2023.2229713. Epub 2023 Jun 28. PMID: 37377210; PMCID: PMC10446773.

________________________________________________________________________________________________________________

The Role of the Gut Microbiome in the Development of Hepatobiliary Cancer

Daniel N, Genua F, Jenab M, Mayén AL, Chrysovalantou Chatziioannou A, Keski-Rahkonen P, Hughes DJ

Hepatology 2023 Apr 15. doi: 10.1097/HEP.0000000000000406. PMID: 37055022.

________________________________________________________________________________________________________________

Pathobionts in the tumour microbiota predict survival following resection for colorectal cancer

Alexander JL, Posma J, Scott A, Poynter L, Mason S, Doria L, McDonald JA, Cameron S, Hughes DJ, Liska V, Susova S, Soucek P, Gomez-Romero M, Herendi L, Lewis MR, Hoyles L, Woolston A, Cunningham D, Darzi A, Gerlinger M, Goldin R, Takats Z, Marchesi JR, Teare J, Kinross J.  

Microbiome 2023 May 8;11(1):100. doi: 10.1186/s40168-023-01518-w. PMID: 37158960; PMCID: PMC10165813.

________________________________________________________________________________________________________________

Dietary intake of total heme and non-heme iron and the risk of colorectal cancer in a European prospective cohort study

Aglago EK, Cross AJ, Riboli E, Fedirko V, Hughes DJ, Fournier A, Jakszyn P, Freisling H, Gunter MJ, Dahm CC, Overvad K, Tjønneland A, Kyrø C, Boutron-Ruault MC, Rothwell JA, Severi G, Katzke V, Srour B, Schulze MB, Wittenbecher C, Palli D, Sieri S, Pasanisi F, Tumino R, Ricceri F, Bueno-de-Mesquita B, Derksen JWG, Skeie G, Jensen TE, Lukic M, Sánchez MJ, Amiano P, Colorado-Yohar S, Barricarte A, Ericson U, van Guelpen B, Papier K, Knuppel A, Casagrande C, Huybrechts I, Heath AK, Tsilidis KK, Jenab M.

Br J Cancer 2023 Feb 128: 1529–1540. doi: 10.1038/s41416-023-02164-7. PMID: 36759722

________________________________________________________________________________________________________________

Pre-diagnostic serum calcium concentrations and risk of colorectal cancer development in two large European prospective cohorts

Karavasiloglou N, Hughes DJ, Murphy N, Schomburg L, Sun Q, Seher V, Rohrmann S, Weiderpass E, Tjønneland A, Olsen A, Overvad K, Boutron-Ruault MC, Mancini FR, Mahamat-Saleh Y, Kaaks R, Kuhn T, Schulze MB, Tumino R, Panico S, Masala G, Pala V, Sacerdote C, Derksen JWG, Skeie G, Hjartåker A, Lasheras C, Agudo A, Sánchez MJ, Chirlaque MD, Ardanaz E, Amiano P, Van Guelpen B, Gylling B, Bradbury KE, Papier K, Freisling H, Aglago EK, Cross AJ, Riboli E, Aune D, Gunter MJ, Jenab M.  

Am J Clin Nutr 2023 Jan 117(1): 33-45, DOI: 10.1016/j.ajcnut.2022.10.004. PMID: 36789942.

_______________________________________________________________________________________________________________________

Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study

Papadimitriou N, Bull CJ, Jenab M, Hughes DJ, Bell JA, Sanderson E, Timpson NJ, Smith GD, Albanes D, Campbell PT, Küry S, Le Marchand L, Ulrich CM, Visvanathan K, Figueiredo JC, Newcomb PA, Pai RK, Peters U, Tsilidis KK, Boer JMA, Vincent EE, Mariosa D, Gunter MJ, Richardson TG, Murphy N.  

BMC Med 2023 Jan 4;21(1):5. doi: 10.1186/s12916-022-02702-9. PMID: 36600297.

_______________________________________________________________________________________________________________________

Unveiling the epigenomic mechanisms of acquired platinum-resistance in high-grade serous ovarian cancer

Silva R., Glennon K., Metoudi M., Moran B., Salta S., Slattedy K., Treacy A., Martin T., Shaw J., Doran P., Lynch L., Jeronimo C., Perry A.S., Brennan D.J.

Int J Cancer. 2023.1- 13. doi:10.1002/ijc.34496. PMID:36883413

________________________________________________________________________________________________________________

Association of COVID-19 mortality with serum selenium, zinc and copper: Six observational studies across Europe

Demircan K, Chillon TS, Bracken T, Bulgarelli I, Campi I, Laing GD, Fafi-Kremer S, Fugazzola L, Garcia AA, Heller R, Hughes DJ, Ide L, Klingenberg GJ, Komarnicki P, Krasinski Z, Lescure A, Mallon P, Moghaddam A, Persani L, Petrovic M, Ruchala M, Solis M, Vandekerckhove L, & Schomburg L.

Front Immunol 2022, Nov 28;13:1022673. doi: 10.3389/fimmu.2022.1022673. PMID: 36518764.

_______________________________________________________________________________________________________________________

Genetically Predicted Circulating Concentrations of Micronutrients and COVID-19 Susceptibility and Severity: A Mendelian Randomization Study

Daniel N, Bouras E, Tsilidis KK, Hughes DJ

Front Nutr 2022, 9:842315. doi: 10.3389/fnut.2022.842315. PMID: 35558754.

_______________________________________________________________________________________________________________________

The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case–Control Studies in Irish and Czech Populations

Mukhtar M, Ashfield N, Vodickova L, Vymetalkova V, Levy M, Liska V, Bruha J, Bendova P, O’Sullivan J, Doherty G, Sheahan K, Nolan B, Vodicka P, & Hughes DJ.

Nutrients 2022, Jun 29;14(13):2718. doi: 10.3390/nu14132718. PMID: 35807897

________________________________________________________________________________________________________________________

Plant-derived cannabinoids as anticancer agents

O’Reilly E.M., Cosgrave J.M., Gallagher W.M., Perry A.S.

Trends Cancer. 2022;8(5):350-357. doi:10.1016/j.trecan.2022.01.017

________________________________________________________________________________________________________________

Emerging role for the Serum Response Factor (SRF) as a potential therapeutic target in cancer

Azam H, Pierro L, Reina M, Gallagher WM, Prencipe M.

Expert Opin Ther Targets. 2022 Feb;26(2):155-169. doi: 10.1080/14728222.2022.2032652. Epub 2022 Feb 11. PMID: 35114091.

________________________________________________________________________________________________________________

Investigating a clinically actionable BRAF mutation for monitoring low-grade serous ovarian cancer: A case report

Silva R., Moran B., Das S., Mulligan N., Doughty M., Treacy A., Sheahan K., Kelly C.M., Duffy A.G., Perry A.S., Brennan D.J.

Case Reports in Women’s Health. 2022. 34:e00395. doi:10.1016/j.crwh.2022.e00395. PMID: 35198414

________________________________________________________________________________________________________________

Longitudinal analysis of individual cfDNA methylome patterns in metastatic prostate cancer

Silva R., Moran B., Baird AM, O’Rourke C.J., Finn S.P., McDermott R., Watson W., Gallagher W.M., Brennan D.J., Perry A.S.

Clin Epigenetics. 2022. 13(1):168. doi:10.1186/s13148-021-01155-w. PMID:34454584

_______________________________________________________________________________________________________________________

Epigenetics and precision medicine in prostate cancer

Jordan A.C., Prencipe M.Silva R., Gallagher W.M., Perry A.S.

Epigenetics and Precision Medicine in Prostate Cancer. Garcia-Gimenez J. (Ed.). Academic Press, 2022. 30:69-108. doi: 10.1016/B978-0-12-823008-4.00008-1.

_______________________________________________________________________________________________________________________

Association of Pre-diagnostic Antibody Responses to Escherichia coli and Bacteroides fragilis Toxin Proteins with Colorectal Cancer in a European Cohort

Butt J, Jenab M, Werner J, Fedirko V, Wild C, Dahm CC, Tjønneland A, Olsen A, Boutron-Ruault MC, Rothwell JA, Severi G, Kaaks R, Turzanski-Fortner R, Aleksandrova K, Schulze M, Palli D, Pala V, Panico S, Tumino R, Sacerdote C, Bueno-de-Mesquita B, van Gils C, Gram I, Lukic M, Sala N, Sanchez Perez MJ, Ardanaz E, Chirlaque MD, Palmquist R, Löwenmark T, Travis RC, Heath A, Cross AJ, Freisling H, Zouiouich S, Aglago E, Waterboer T & Hughes DJ

Gut Microbes 2021, 13(1): 1-14 DOI: 10.1080/19490976.2021.1903825. PMID: 33874856

_______________________________________________________________________________________________________________________

The role of Gut Barrier Dysfunction and Microbiome Dysbiosis in Colorectal Cancer development

Genua F, Raghunathan V, Jenab M, Gallagher WM, & Hughes DJ.

Front Oncol 2021 Apr 15;11:626349. doi: 10.3389/fonc.2021.626349. PMID: 33937029.

_______________________________________________________________________________________________________________________

Association of circulating Short Chain Fatty Acid levels with Colorectal Adenomas and Colorectal Cancer

Genua F, Mullee A, Mirkovic B, Levy M, Vodicka P, Gallagher WM, & Hughes DJ. 

Clin Nutr ESPEN 2021 October 5th, DOI: 10.1016/j.clnesp.2021.09.740. PMID: 34857211

_______________________________________________________________________________________________________________________

Prediagnostic Blood Selenium Status and Mortality among Patients with Colorectal Cancer in Western European Populations

Baker JR, Umesh S, Jenab M, Schomburg L, Tjønneland A, Olsen A, Boutron-Ruault M-C, Rothwell JA, Severi G, Katzke V, Johnson T, Schulze MB, Masala G, Agnoli C, Simeon V, Tumino R, Bueno-de-Mesquita HB, Gram IT, Skeie G, Bonet C, Rodriguez-Barranco M, Houerta JM, Gylling B, Van Guelpen B, Perez-Cornago A, Aglago E, Freisling H, Weiderpass E, Cross AJ, Heath AK, Hughes DJ*, Fedirko V* (*equal lead). 

Biomedicines 2021; October 22nd, 9(11):1521. doi: 10.3390/biomedicines9111521. PMID: 34829750

_______________________________________________________________________________________________________________________

Dietary Advanced Glycation End-Products and Colorectal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Aglago EK, Mayén A-L, Knaze V, Freisling H, Fedirko V, Hughes DJ, Jiao L, Eriksen AK, Tjønneland A, Boutron-Ruault M-C, Rothwell JA, Severi G, Kaaks R, Katzke V, Schulze MB, Birukov A, Palli D, Sieri S, Santucci de Magistris M, Tumino R, Ricceri F, Bueno-de-Mesquita B, Derksen JWG, Skeie G, Gram IT, Sandanger T, Quirós JR, Luján-Barroso L, Sánchez M-J, Amiano P, Chirlaque M-D, Gurrea AB, Johansson I, Manjer J, Perez-Cornago A, Weiderpass E, Gunter MJ, Heath AK, Schalkwijk CG, Jenab M. 

Nutrients 2021; 13(9):3132. doi: 10.3390/nu13093132. PMID: 34579010.

________________________________________________________________________________________________________________

Dietary Intake of Advanced Glycation End Products (AGEs) and Mortality Among Individuals with Colorectal Cancer

Mao Z, Aglago EK, Zhao Z, Schalkwijk C, Li J, Freisling H, Weiderpass E, Hughes DJ, Eriksen AK, Tjønneland A, Severi G, Rothwell J, Boutron-Ruault M-C, Katzke V, Kaaks R, Schulze MB, Birukov A, Krogh V, Panico S, Tumino R, Ricceri F, Bueno-de-Mesquita HB, Vermeulen RCH, Gram IT, Skeie G, Sandanger TM, Quirós JR, Crous-Bou M, Sánchez M-J, Amiano P, Chirlaque M-D, Barricarte Gurrea A, Manjer J, Johansson I, Perez-Cornago A, Jenab M, Fedirko V. 

Nutrients 2021; 13(12):4435. DOI: 10.3390/nu13124435. PMID: 34959986.

________________________________________________________________________________________________________________

Plasma concentrations of advanced glycation end-products and colorectal cancer risk in the EPIC stud

Aglago EK, Schalkwijk CG, Freisling H, Fedirko V, Hughes DJ, Jiao L, Dahm CC, Olsen A, Tjønneland A, Katzke V, Johnson T, Schulze MB, Aleksandrova K, Masala G, Sieri S, Simeon V, Tumino R, Macciotta A, Bueno-de-Mesquita B, Skeie G, Gram IT, Sandanger T, Jakszyn P, Sánchez MJ, Amiano P, Colorado-Yohar SM, Gurrea AB, Perez-Cornago A, Mayén AL, Weiderpass E, Gunter MJ, Heath AK, Jenab M. 

Carcinogenesis 2021 May 28;42(5):705-713. doi: 10.1093/carcin/bgab026. PMID: 33780524.

________________________________________________________________________________________________________________

Genetically predicted circulating concentrations of micronutrients and risk of colorectal cancer among individuals of European descent: a Mendelian randomization study

Tsilidis KK, Papadimitriou N, Dimou N, Gill D, Lewis SJ, Martin RM, Murphy N, Markozannes G, Zuber V, Cross AJ, Burrows K, Lopez DS, Key TJ, Travis RC, Perez-Cornago A, Hunter DJ, van Duijnhoven FJB, Albanes D, Arndt V, Berndt SI, Bézieau S, Bishop DT, Boehm J, Brenner H, Burnett-Hartman A, Campbell PT, Casey G, Castellví-Bel S, Chan AT, Chang-Claude J, de la Chapelle A, Figueiredo JC, Gallinger SJ, Giles GG, Goodman PJ, Gsur A, Hampe J, Hampel H, Hoffmeister M, Jenkins MA, Keku TO, Kweon SS, Larsson SC, Le Marchand L, Li CI, Li L, Lindblom A, Martín V, Milne RL, Moreno V, Nan H, Nassir R, Newcomb PA, Offit K, Pharoah PDP, Platz EA, Potter JD, Qi L, Rennert G, Sakoda LC, Schafmayer C, Slattery ML, Snetselaar L, Schenk J, Thibodeau SN, Ulrich CM, Van Guelpen B, Harlid S, Visvanathan K, Vodickova L, Wang H, White E, Wolk A, Woods MO, Wu AH, Zheng W, Bueno-de-Mesquita B, Boutron-Ruault MC, Hughes DJ, Jakszyn P, Kühn T, Palli D, Riboli E, Giovannucci EL, Banbury BL, Gruber SB, Peters U, Gunter MJ.

Am J Clin Nutr 2021 Jun 1;113(6):1490-1502. doi: 10.1093/ajcn/nqab003. PMID: 33740060.

________________________________________________________________________________________________________________

Toenail selenium, plasma selenoprotein P and risk of advanced prostate cancer: a nested case-control study

Outzen M, Tjønneland A, Hughes DJ, Jenab M, Frederiksen K, Schomburg L, Morris S, Overvad K, Olsen A. 

Int J Cancer 2021 Feb 15;148(4):876-883. doi: 10.1002/ijc.33267. Epub 2020 Sep 4. PMID: 32838475.

________________________________________________________________________________________________________________

Soluble Receptor for Advanced Glycation End-products (sRAGE) and colorectal cancer risk: a case-control study nested within a European prospective cohort

Aglago EK, Rinaldi S, Freisling H, Jiao L, Hughes DJ, Fedirko V, Schalkwijk CG, Weiderpass E, Dahm CC, Overvad K, Eriksen AK, Kyrø C, Boutron-Ruault MC, Rothwell JA, Severi G, Katzke V, Kühn T, Schulze MB, Aleksandrova K, Masala G, Krogh V, Panico S, Tumino R, Naccarati A, Bueno-de-Mesquita B, van Gils CH, Sandanger TM, Gram IT, Skeie G, Quirós JR, Jakszyn P, Sánchez MJ, Amiano P, Huerta JM, Ardanaz E, Johansson I, Harlid S, Perez-Cornago A, Mayén AL, Cordova R, Gunter MJ, Vineis P, Cross AJ, Riboli E, Jenab M.

Cancer Epidemiol Biomarkers Prev 2021 Jan;30(1):182-192. doi: 10.1158/1055-9965.EPI-20-0855. Epub 2020 Oct 20. PMID: 33082206

________________________________________________________________________________________________________________

Metabolic Signatures of Healthy Lifestyle Patterns and Colorectal Cancer Risk in a European Cohort.

Rothwell JA, Murphy N, Bešević J, Kliemann N, Jenab M, Ferrari P, Achaintre D, Gicquiau A, Vozar B, Scalbert A, Huybrechts I, Freisling H, Prehn C, Adamski J, Cross AJ, Pala VM, Boutron-Ruault MC, Dahm CC, Overvad K, Gram IT, Sandanger TM, Skeie G, Jakszyn P, Tsilidis KK, Aleksandrova K, Schulze MB, Hughes DJ, van Guelpen B, Bodén S, Sánchez MJ, Schmidt JA, Katzke V, Kühn T, Colorado-Yohar S, Tumino R, Bueno-de-Mesquita B, Vineis P, Masala G, Panico S, Eriksen AK, Tjønneland A, Aune D, Weiderpass E, Severi G, Chajès V, Gunter MJ.

Clin Gastroenterol Hepatol 2020 Dec 3:S1542-3565(20)31635-9. doi: 10.1016/j.cgh.2020.11.045. PMID: 33279777.

________________________________________________________________________________________________________________

Inhibition of Serum Response Factor Improves Response to Enzalutamide in Prostate Cancer

Watson RW, Azam H, Aura C, Russell N, McCormack J, Corey E, Morrissey C, Crown J, Gallagher WM, Prencipe M.

Cancers (Basel). 2020 Nov 27;12(12):3540. doi: 10.3390/cancers12123540. PMID: 33260953; PMCID: PMC7760758.

________________________________________________________________________________________________________________

Evaluating liquid biopsies for methylomic profiling of prostate cancer.

Silva R, Moran B, Russell NM, Fahey C, Vlajnic T, Manecksha RP, Finn SP, Brennan DJ, Gallagher WM, Perry AS.

Epigenetics. 2020 Jun-Jul;15(6-7):715-727. doi: 10.1080/15592294.2020.1712876. Epub 2020 Jan 31.PMID: 32000564

________________________________________________________________________________________________________________

Multi-Gene Prognostic Signatures and Prediction of Pathological Complete Response to Neoadjuvant Chemotherapy in ER-positive, HER2-negative Breast Cancer Patients.

Mazo C, Barron S, Mooney C, Gallagher WM.Cancers (Basel). 2020 May 1;12(5):E1133. doi: 10.3390/cancers12051133.PMID: 32369904 Free article.

________________________________________________________________________________________________________________

Development of a multivariable risk model integrating urinary cell DNA methylation and cell-free RNA data for the detection of significant prostate cancer

Connell SP, O’Reilly E, Tuzova A, Webb M, Hurst R, Mills R, Zhao F, Bapat B, Cooper CS, Perry AS, Clark J, Brewer DS.Prostate. 2020 May;80(7):547-558. doi: 10.1002/pros.23968. Epub 2020 Mar 9.PMID: 32153047

________________________________________________________________________________________________________________

Antibody responses to Helicobacter pylori and risk of developing colorectal cancer in a European cohort.

Butt J, Jenab M, Pawlita M, Tjønneland A, Kyrø C, Boutron-Ruault MC, Carbonnel F, Dong C, Kaaks R, Kühn T, Boeing H, Schulze M, Trichopoulou A, Karakatsani A, la Vecchia C, Palli D, Agnoli C, Tumino R, Sacerdote C, Panico S, Bueno-de-Mesquita B, Vermeulen RCH, Gram IT, Weiderpass E Benjaminsen Borch K, Ramón Quirós J, Agudo A, Rodríguez-Barranco M, Santiuste C, Ardanaz E, van Guelpen B, Harlid S, Imaz L, Perez-Cornago A Gunter MJ, Zouiouich S, Park JY, Riboli E, Cross AJ, Heath AK, Waterboer T,  Hughes DJ.

Cancer Epidemiol Biomark Prev 2020, Apr 24. pii: cebp.1545.2019. doi: 10.1158/1055-9965.EPI-19-1545. PMID: 32332031.

________________________________________________________________________________________________________________

Triple Combination of Ascorbate, Menadione and the Inhibition of Peroxiredoxin-1 Produces Synergistic Cytotoxic Effects in Triple-Negative Breast Cancer Cells.

Bajor M, Graczyk-Jarzynka A, Marhelava K, Kurkowiak M, Rahman A, Aura C, Russell N, Zych AO, Firczuk M, Winiarska M, Gallagher WM, Zagozdzon R.   Antioxidants (Basel). 2020 Apr 16;9(4):320. doi: 10.3390/antiox9040320.PMID: 32316111 Free PMC article.

________________________________________________________________________________________________________________

The Role of Selenium in Health and Disease: Emerging and recurring trends.

Méplan C, Hughes DJNutrients 2020, Apr 10;12(4). pii: E1049. doi:10.3390/nu12041049. PMID: 32290296

________________________________________________________________________________________________________________

Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma.

Guttà C, Rahman A, Aura C, Dynoodt P, Charles EM, Hirschenhahn E, Joseph J, Wouters J, de Chaumont C, Rafferty M, Warren M, van den Oord JJ, Gallagher WM, Rehm M.Cell Death Dis. 2020 Feb 13;11(2):124. doi: 10.1038/s41419-020-2309-3.PMID: 32054850 Free PMC article.

________________________________________________________________________________________________________________

Clinical Decision Support Systems in Breast Cancer: A Systematic Review.

Mazo C, Kearns C, Mooney C, Gallagher WM.Cancers (Basel). 2020 Feb 6;12(2):369. doi: 10.3390/cancers12020369.PMID: 32041094 Free PMC article. Review.

________________________________________________________________________________________________________________

An EPR Strategy for Bio-responsive Fluorescence Guided Surgery with Simulation of the Benefit for Imaging.

Daly HC, Conroy E, Todor M, Wu D, Gallagher WM, O’Shea DF.Theranostics. 2020 Feb 10;10(7):3064-3082. doi: 10.7150/thno.42702. eCollection 2020.PMID: 32194855 Free PMC article.

________________________________________________________________________________________________________________

Validation of the OncoMasTR Risk Score in Estrogen Receptor-Positive/HER2-Negative Patients: A TransATAC study.

Buus R, Sestak I, Barron S, Loughman T, Fender B, Ruiz CL, Dynoodt P, Wang CA, O’Leary D, Gallagher WM, Dowsett M, Cuzick J.Clin Cancer Res. 2020 Feb 1;26(3):623-631. doi: 10.1158/1078-0432.CCR-19-0712. Epub 2019 Oct 22.PMID: 31641007 .

_______________________________________________________________________________________________________________________

Expression quantitative trait loci in ABC transporters are associated with survival in 5-FU treated colorectal cancer patients.

Vymetalkova, V., Rosa, F., Susova, S., Bendova, P., Levy, M., Buchler, T., Kral, J., Bartu, L., Vodickova, L., Hughes, D. J., Soucek, P., Naccarati, A., Kumar, R., Vodicka, P. and Pardini, B.

Mutagenesis. 2020 Jan 10. pii: gez050. doi: 10.1093/mutage/gez050. [Epub ahead of print]

_______________________________________________________________________________________________________________________

Holding a MIRror up to the robustness of the prostate cancer urinary transcriptome

Connor AE, Jordan AC, Perry AS.Transl Androl Urol. 2019 Dec;8(Suppl 5):S488-S490. doi: 10.21037/tau.2019.09.25.PMID: 32042627 Free PMC article.

_______________________________________________________________________________________________________________________

BET Inhibition as a Rational Therapeutic Strategy for Invasive Lobular Breast Cancer.

Walsh L, Haley KE, Moran B, Mooney B, Tarrant F, Madden SF, Di Grande A, Fan Y, Das S, Rueda OM, Dowling CM, Varešlija D, Chin SF, Linn S, Young LS, Jirström K, Crown JP, Bernards R, Caldas C, Gallagher WM, O’Connor DP, Ní Chonghaile T.

Clin Cancer Res. 2019 Dec 1;25(23):7139-7150. doi: 10.1158/1078-0432.CCR-19-0713. Epub 2019 Aug 13.

PMID: 31409615

________________________________________________________________________________________________________________________

Validation of the OncoMasTR Risk Score in Estrogen Receptor-Positive/HER2-Negative Patients: A TransATAC study.

Buus R, Sestak I, Barron S, Loughman T, Fender B, Ruiz CL, Dynoodt P, Wang CA, O’Leary D, Gallagher WM, Dowsett M, Cuzick J.

Clin Cancer Res. 2019 Oct 22. doi: 10.1158/1078-0432.CCR-19-0712. [Epub ahead of print]

PMID: 31641007

________________________________________________________________________________________________________________________

Association of selenium status and selenoprotein genetic variations with cancer risk

Hughes DJ, Fedirko V, Schomburg L, Hybsier S, Méplan C, Jenab M. Association of selenium status and selenoprotein genetic variations with cancer risk. In Book: Selenium Research for Environment and Human Health: Perspectives, Technologies and Advancements 2019 Oct 1st 2019; pp 165-166 (editors Bañuelos G, Lin ZQ, Liang D, Yin XB) 1st Ed, CRC Press, Taylor & Francis, Oxford, UK. ISBN 9781138390140.

_______________________________________________________________________________________________________________________

Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients.

Kunzmann AT, Proença MA, Jordao HW, Jiraskova K, Schneiderova M, Levy M, Liska V, Buchler T, Vodickova L, Vymetalkova V, Silva AE, Vodicka P, Hughes DJ.

Eur J Clin Microbiol Infect Dis. 2019 Oct;38(10):1891-1899. doi: 10.1007/s10096-019-03649-1. Epub 2019 Jul 31.

PMID: 31367996  Free PMC Article

________________________________________________________________________________________________________________________

Lifestyle and dietary environmental factors in colorectal cancer susceptibility.

Murphy N, Moreno V, Hughes DJ, Vodicka L, Vodicka P, Aglago EK, Gunter MJ, Jenab M.

Mol Aspects Med. 2019 Oct;69:2-9. doi: 10.1016/j.mam.2019.06.005. Epub 2019 Jun 28. Review.

PMID: 31233770

________________________________________________________________________________________________________________________

Antibody Responses to Fusobacterium nucleatum Proteins in Prediagnostic Blood Samples are not Associated with Risk of Developing Colorectal Cancer.

Butt J, Jenab M, Pawlita M, Overvad K, Tjonneland A, Olsen A, Boutron-Ruault MC, Carbonnel F, Mancini FR, Kaaks R, Kühn T, Boeing H, Trichopoulou A, Karakatsani A, Palli D, Pala VM, Tumino R, Sacerdote C, Panico S, Bueno-de-Mesquita B, van Gils CH, Vermeulen RCH, Weiderpass E, Quirós JR, Duell EJ, Sánchez MJ, Dorronsoro M, Huerta JM, Ardanaz E, Van Guelpen B, Harlid S, Perez-Cornago A, Gunter MJ, Murphy N, Freisling H, Aune D, Waterboer T, Hughes DJ.

Cancer Epidemiol Biomarkers Prev. 2019 Sep;28(9):1552-1555. doi: 10.1158/1055-9965.EPI-19-0313.

PMID:31481495

________________________________________________________________________________________________________________________

International Cancer Microbiome Consortium consensus statement on the role of the human microbiome in carcinogenesis.

Scott AJ, Alexander JL, Merrifield CA, Cunningham D, Jobin C, Brown R, Alverdy J, O’Keefe SJ, Gaskins HR, Teare J, Yu J, Hughes DJ, Verstraelen H, Burton J, O’Toole PW, Rosenberg DW, Marchesi JR, Kinross JM.

Gut. 2019 Sep;68(9):1624-1632. doi: 10.1136/gutjnl-2019-318556. Epub 2019 May 15.

PMID: 31092590   Free PMC Article

________________________________________________________________________________________________________________________

Novel Strategies for Cancer Treatment: Highlights from the 55th IACR Annual Conference.

Charmsaz S, Collins DM, Perry AS, Prencipe M.

Cancers (Basel). 2019 Aug 7;11(8). pii: E1125. doi: 10.3390/cancers11081125.

PMID: 31394729  Free PMC Article

________________________________________________________________________________________________________________________

Vitamin D-Related Genes, Blood Vitamin D Levels and Colorectal Cancer Risk in Western European Populations.

Fedirko V, Mandle HB, Zhu W, Hughes DJ, Siddiq A, Ferrari P, Romieu I, Riboli E, Bueno-de-Mesquita B, van Duijnhoven FJB, Siersema PD, Tjønneland A, Olsen A, Perduca V, Carbonnel F, Boutron-Ruault MC, Kühn T, Johnson T, Krasimira A, Trichopoulou A, Makrythanasis P, Thanos D, Panico S, Krogh V, Sacerdote C, Skeie G, Weiderpass E, Colorado-Yohar S, Sala N, Barricarte A, Sanchez MJ, Quirós R, Amiano P, Gylling B, Harlid S, Perez-Cornago A, Heath AK, Tsilidis KK, Aune D, Freisling H, Murphy N, Gunter MJ, Jenab M.

Nutrients. 2019 Aug 20;11(8). pii: E1954. doi: 10.3390/nu11081954.

PMID: 31434255   Free PMC Article

________________________________________________________________________________________________________________________

RGD conjugated cell uptake off to on responsive NIR-AZA fluorophores: applications toward intraoperative fluorescence guided surgery.

Wu D, Daly HC, Grossi M, Conroy E, Li B, Gallagher WM, Elmes R, O’Shea DF.

Chem Sci. 2019 Jun 21;10(29):6944-6956. doi: 10.1039/c9sc02197c. eCollection 2019 Aug 7.

PMID: 31588261  Free PMC Article

________________________________________________________________________________________________________________________

Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents.

Miller IS, Shiels LP, Conroy E, Connor K, Dicker P, Gallagher WM, Donovan NO, Kerbel RS, Crown J, Byrne AT.

Sci Rep. 2019 Jun 24;9(1):9204. doi: 10.1038/s41598-019-45444-0.

PMID: 31235775  Free PMC Article

________________________________________________________________________________________________________________________

1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours.

Butler CT, Kennedy SA, Buckley A, Doyle R, Conroy E, Gallagher WM, O’Sullivan J, Kennedy BN.

Oncotarget. 2019 Jun 4;10(38):3725-3744. doi: 10.18632/oncotarget.26966. eCollection 2019 Jun 4.

PMID: 31217905  Free PMC Article

________________________________________________________________________________________________________________________

A Four-Group Urine Risk Classifier for Predicting Outcome in Prostate Cancer Patients.

Connell SP, Hanna M, McCarthy F, Hurst R, Webb M, Curley H, Walker H, Mills R, Ball RY, Sanda MG, Pellegrini KL, Patil D, Perry AS, Schalken J, Pandha H, Whitaker H, Dennis N, Stuttle C, Mills IG, Guldvik I; Movember GAP1 Urine Biomarker Consortium, Parker C, Brewer DS, Cooper CS, Clark J.

BJU Int. 2019 May 20. doi: 10.1111/bju.14811. [Epub ahead of print]

PMID: 31106513  Free PMC Article

________________________________________________________________________________________________________________________

Association of Selenoprotein and Selenium Pathway Genotypes with Risk of Colorectal Cancer and Interaction with Selenium Status.

Fedirko V, Jenab M, Méplan C, Jones JS, Zhu W, Schomburg L, Siddiq A, Hybsier S, Overvad K, Tjønneland A, Omichessan H, Perduca V, Boutron-Ruault MC, Kühn T, Katzke V, Aleksandrova K, Trichopoulou A, Karakatsani A, Kotanidou A, Tumino R, Panico S, Masala G, Agnoli C, Naccarati A, Bueno-de-Mesquita B, Vermeulen RCH, Weiderpass E, Skeie G, Nøst TH, Lujan-Barroso L, Quirós JR, Huerta JM, Rodríguez-Barranco M, Barricarte A, Gylling B, Harlid S, Bradbury KE, Wareham N, Khaw KT, Gunter M, Murphy N, Freisling H, Tsilidis K, Aune D, Riboli E, Hesketh JE, Hughes DJ.

Nutrients. 2019 Apr 25;11(4). pii: E935. doi: 10.3390/nu11040935.

PMID: 31027226   Free PMC Article

________________________________________________________________________________________________________________________

A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic.

Salvucci M, Rahman A, Resler AJ, Udupi GM, McNamara DA, Kay EW, Laurent-Puig P, Longley DB, Johnston PG, Lawler M, Wilson R, Salto-Tellez M, Van Schaeybroeck S, Rafferty M, Gallagher WM, Rehm M, Prehn JHM.

JCO Clin Cancer Inform. 2019 Apr;3:1-17. doi: 10.1200/CCI.18.00056.

PMID: 30995124  Free Article

________________________________________________________________________________________________________________________

PDLIM2 Is a Marker of Adhesion and β-Catenin Activity in Triple-Negative Breast Cancer.

Cox OT, Edmunds SJ, Simon-Keller K, Li B, Moran B, Buckley NE, Bustamante-Garrido M, Healy N, O’Flanagan CH, Gallagher WM, Kennedy RD, Bernards R, Caldas C, Chin SF, Marx A, O’Connor R.

Cancer Res. 2019 May 15;79(10):2619-2633. doi: 10.1158/0008-5472.CAN-18-2787. Epub 2019 Mar 18.

PMID: 30885980

________________________________________________________________________________________________________________________

epiCaPture: A Urine DNA Methylation Test for Early Detection of Aggressive Prostate Cancer.

O’Reilly E, Tuzova AV, Walsh AL, Russell NM, O’Brien O, Kelly S, Dhomhnallain ON, DeBarra L, Dale CM, Brugman R, Clarke G, Schmidt O, O’Meachair S, Patil D, Pellegrini KL, Fleshner N, Garcia J, Zhao F, Finn S, Mills R, Hanna MY, Hurst R, McEvoy E, Gallagher WM, Manecksha RP, Cooper CS, Brewer DS, Bapat B, Sanda MG, Clark J, Perry AS.

JCO Precis Oncol. 2019;2019. doi: 10.1200/PO.18.00134. Epub 2019 Jan 14.

PMID: 30801051  Free PMC Article

________________________________________________________________________________________________________________________

Targeted DNA Methylation Profiling of Human Cardiac Tissue Reveals Novel Epigenetic Traits and Gene Deregulation Across Different Heart Failure Patient Subtypes.

Glezeva N, Moran B, Collier P, Moravec CS, Phelan D, Donnellan E, Russell-Hallinan A, O’Connor DP, Gallagher WM, Gallagher J, McDonald K, Ledwidge M, Baugh J, Das S, Watson CJ.

Circ Heart Fail. 2019 Mar;12(3):e005765. doi: 10.1161/CIRCHEARTFAILURE.118.005765.

PMID: 30798618

________________________________________________________________________________________________________________________

Implementing Reverse Phase Protein Array Profiling as a Sensitive Method for the Early Pre-Clinical Detection of Off-Target Toxicities Associated with Sunitinib Malate.

O’Farrell AC, Miller IS, Evans R, Alamanou M, Cary M, Mallya Udupi G, Lafferty A, Monsefi N, Cremona M, Prehn JHM, Verheul HM, Gallagher WM, Gehrmann M, Byrne AT.

Proteomics Clin Appl. 2019 Jul;13(4):e1800159. doi: 10.1002/prca.201800159. Epub 2019 Mar 19.

PMID: 30768761

________________________________________________________________________________________________________________________

PEGylated BF2-Azadipyrromethene (NIR-AZA) fluorophores, for intraoperative imaging.

Wu D, Daly HC, Conroy E, Li B, Gallagher WM, Cahill RA, O’Shea DF.

Eur J Med Chem. 2019 Jan 1;161:343-353. doi: 10.1016/j.ejmech.2018.10.046. Epub 2018 Oct 19.

PMID: 30368132

________________________________________________________________________________________________________________________

Relationship between Fusobacterium nucleatum, inflammatory mediators and microRNAs in colorectal carcinogenesis.

Proença MA, Biselli JM, Succi M, Severino FE, Berardinelli GN, Caetano A, Reis RM, Hughes DJ, Silva AE.

World J Gastroenterol. 2018 Dec 21;24(47):5351-5365. doi: 10.3748/wjg.v24.i47.5351.

PMID: 30598580  Free PMC Article

________________________________________________________________________________________________________________________

Functional Polymorphisms in DNA Repair Genes Are Associated with Sporadic Colorectal Cancer Susceptibility and Clinical Outcome.

Jiraskova K, Hughes DJ, Brezina S, Gumpenberger T, Veskrnova V, Buchler T, Schneiderova M, Levy M, Liska V, Vodenkova S, Di Gaetano C, Naccarati A, Pardini B, Vymetalkova V, Gsur A, Vodicka P.

Int J Mol Sci. 2018 Dec 27;20(1). pii: E97. doi: 10.3390/ijms20010097.

PMID: 30591675  Free PMC Article

________________________________________________________________________________________________________________________

A urine-based DNA methylation assay, ProCUrE, to identify clinically significant prostate cancer.

Zhao F, Olkhov-Mitsel E, Kamdar S, Jeyapala R, Garcia J, Hurst R, Hanna MY, Mills R, Tuzova AV, O’Reilly E, Kelly S, Cooper C; Movember Urine Biomarker Consortium, Brewer D, Perry AS, Clark J, Fleshner N, Bapat B.

Clin Epigenetics. 2018 Nov 23;10(1):147. doi: 10.1186/s13148-018-0575-z.

PMID: 30470249  Free PMC Article

________________________________________________________________________________________________________________________

Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer.

Hughes DJ, Kunická T, Schomburg L, Liška V, Swan N, Souček P.

Nutrients. 2018 Nov 21;10(11). pii: E1812. doi: 10.3390/nu10111812.

PMID: 30469315  Free PMC Article

________________________________________________________________________________________________________________________

Development of acquired resistance to lapatinib may sensitise HER2-positive breast cancer cells to apoptosis induction by obatoclax and TRAIL.

Eustace AJ, Conlon NT, McDermott MSJ, Browne BC, O’Leary P, Holmes FA, Espina V, Liotta LA, O’Shaughnessy J, Gallagher C, O’Driscoll L, Rani S, Madden SF, O’Brien NA, Ginther C, Slamon D, Walsh N, Gallagher WM, Zagozdzon R, Watson WR, O’Donovan N, Crown J.

BMC Cancer. 2018 Oct 11;18(1):965. doi: 10.1186/s12885-018-4852-1.

PMID: 30305055 Free PMC Article

________________________________________________________________________________________________________________________

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy.

Smeets D, Miller IS, O’Connor DP, Das S, Moran B, Boeckx B, Gaiser T, Betge J, Barat A, Klinger R, van Grieken NCT, Cremolini C, Prenen H, Mazzone M, Depreeuw J, Bacon O, Fender B, Brady J, Hennessy BT, McNamara DA, Kay E, Verheul HM, Maarten N, Gallagher WM, Murphy V, Prehn JHM, Koopman M, Punt CJA, Loupakis F, Ebert MPA, Ylstra B, Lambrechts D, Byrne AT.

Nat Commun. 2018 Oct 5;9(1):4112. doi: 10.1038/s41467-018-06567-6.

PMID: 30291241  Free PMC Article

________________________________________________________________________________________________________________________

Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers.

Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM.

J Mol Med (Berl). 2018 Oct;96(10):1025-1037. doi: 10.1007/s00109-018-1675-0. Epub 2018 Aug 1.

PMID: 30069746

________________________________________________________________________________________________________________________

Integrating biomarkers across omic platforms: an approach to improve stratification of patients with indolent and aggressive prostate cancer.

Murphy K, Murphy BT, Boyce S, Flynn L, Gilgunn S, O’Rourke CJ, Rooney C, Stöckmann H, Walsh AL, Finn S, O’Kennedy RJ, O’Leary J, Pennington SR, Perry AS, Rudd PM, Saldova R, Sheils O, Shields DC, Watson RW.

Mol Oncol. 2018 Sep;12(9):1513-1525. doi: 10.1002/1878-0261.12348. Epub 2018 Aug 7.

PMID: 29927052  Free PMC Article

________________________________________________________________________________________________________________________

Epigenetics of malignant melanoma.

Moran B, Silva R, Perry AS,Gallagher WM.

Semin Cancer Biol. 2018 Aug;51:80-88. doi: 10.1016/j.semcancer.2017.10.006. Epub 2017 Oct 23. Review.

PMID: 29074395

________________________________________________________________________________________________________________________

Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab.

van Dijk E, Biesma HD, Cordes M, Smeets D, Neerincx M, Das S, Eijk PP, Murphy V, Barat A, Bacon O, Prehn JHM, Betge J, Gaiser T, Fender B, Meijer GA, McNamara DA, Klinger R, Koopman M, Ebert MPA, Kay EW, Hennessey BT, Verheul HMW, Gallagher WM, O’Connor DP, Punt CJA, Loupakis F, Lambrechts D, Byrne AT, van Grieken NCT, Ylstra B.

J Clin Oncol. 2018 Jul 10;36(20):2052-2060. doi: 10.1200/JCO.2017.77.1782. Epub 2018 May 24.

PMID: 29792754

________________________________________________________________________________________________________________________

Role of serum response factor expression in prostate cancer biochemical recurrence.

Prencipe M, Fabre A, Murphy TB, Vargyas E, O’Neill A, Bjartell A, Tasken KA, Grytli HH, Svindland A, Berge V, Eri LM, Gallagher W, Watson RW.

Prostate. 2018 Jul;78(10):724-730. doi: 10.1002/pros.23516. Epub 2018 Apr 2.

PMID: 29608018

________________________________________________________________________________________________________________________

Innovative Technologies Changing Cancer Treatment.

Charmsaz S, Prencipe M, Kiely M, Pidgeon GP, Collins DM.

Cancers (Basel). 2018 Jun 19;10(6). pii: E208. doi: 10.3390/cancers10060208.

PMID: 29921753   Free PMC Article

________________________________________________________________________________________________________________________

Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379.

O’Brien KP, Khan S, Gilligan KE, Zafar H, Lalor P, Glynn C, O’Flatharta C, Ingoldsby H, Dockery P, De Bhulbh A, Schweber JR, St John K, Leahy M, Murphy JM, Gallagher WM, O’Brien T, Kerin MJ, Dwyer RM.

Oncogene. 2018 Apr;37(16):2137-2149. doi: 10.1038/s41388-017-0116-9. Epub 2018 Jan 25.

PMID: 29367765

________________________________________________________________________________________________________________________

Assessing DNA Methylation in Cancer Stem Cells.

Das S, Moran B, Perry AS.

Methods Mol Biol. 2018;1692:157-178. doi: 10.1007/978-1-4939-7401-6_15.

PMID: 28986896

________________________________________________________________________________________________________________________

Mutant p53 as a therapeutic target for the treatment of triple-negative breast cancer: Preclinical investigation with the anti-p53 drug, PK11007.

Synnott NC, Bauer MR, Madden S, Murray A, Klinger R, O’Donovan N, O’Connor D, Gallagher WM, Crown J, Fersht AR, Duffy MJ.

Cancer Lett. 2018 Feb 1;414:99-106. doi: 10.1016/j.canlet.2017.09.053. Epub 2017 Oct 22.

PMID: 29069577

________________________________________________________________________________________________________________________

Prospective evaluation of antibody response to Streptococcus gallolyticus and risk of colorectal cancer.

Butt J, Jenab M, Willhauck-Fleckenstein M, Michel A, Pawlita M, Kyrø C, Tjønneland A, Boutron-Ruault MC, Carbonnel F, Severi G, Kaaks R, Kühn T, Boeing H, Trichopoulou A, la Vecchia C, Karakatsani A, Panico S, Tumino R, Agnoli C, Palli D, Sacerdote C, Bueno-de-Mesquita B, Weiderpass E, Sánchez MJ, Bonet Bonet C, Huerta J, Ardanaz E, Bradbury K, Gunter M, Murphy N, Freisling H, Riboli E, Tsilidis K, Aune D, Waterboer T, Hughes D.

Int J Cancer. 2018 Jan 29. doi: 10.1002/ijc.31283. [Epub ahead of print]

PMID:29377173

________________________________________________________________________________________________________________________


Employing mesenchymal stem cells to support tumor-targeted delivery of extracellular vesicle (EV)-encapsulated microRNA-379.

O’Brien KP, Khan S, Gilligan KE, Zafar H, Lalor P, Glynn C, O’Flatharta C, Ingoldsby H, Dockery P, De Bhulbh A, Schweber JR, St John K, Leahy M, Murphy JM, Gallagher WM, O’Brien T, Kerin MJ, Dwyer RM.

Oncogene. 2018 Jan 25. doi: 10.1038/s41388-017-0116-9. [Epub ahead of print]

PMID:29367765

________________________________________________________________________________________________________________________

Absolute Quantification of Toxicological Biomarkers via Mass Spectrometry.

Lau TYK, Collins BC, Stone P, Tang N, Gallagher WM, Pennington SR.

Methods Mol Biol. 2017;1641:337-348. doi: 10.1007/978-1-4939-7172-5_19.

PMID:28748474

________________________________________________________________________________________________________________________

Epigenetics of malignant melanoma.

Moran B, Silva R, Perry AS, Gallagher WM.

Semin Cancer Biol. 2017 Oct 23. pii: S1044-579X(17)30130-X. doi: 10.1016/j.semcancer.2017.10.006. [Epub ahead of print] Review.

PMID:29074395

________________________________________________________________________________________________________________________

Analysis of urinary PSA glycosylation is not indicative of high-risk prostate cancer.

Barrabés S, Llop E, Ferrer-Batallé M, Ramírez M, Aleixandre RN, Perry AS, de Llorens R, Peracaula R.

Clin Chim Acta. 2017 Jul;470:97-102. doi: 10.1016/j.cca.2017.05.009. Epub 2017 May 8.

PMID:28495148

________________________________________________________________________________________________________________________

Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach.

Moran B, Das S, Smeets D, Peutman G, Klinger R, Fender B, Connor K, Ebert M, Gaiser T, Prehn JH, Bacon O, Kay E, Hennessy B, Murphy V, Ylstra B, Lambrechts D, Byrne AT, Gallagher WM, O’Connor DP.

Oncotarget. 2017 Jul 18;8(29):48126-48137. doi: 10.18632/oncotarget.18296.

PMID:28611295

________________________________________________________________________________________________________________________

Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma.

Wouters J, Vizoso M, Martinez-Cardus A, Carmona FJ, Govaere O, Laguna T, Joseph J, Dynoodt P, Aura C, Foth M, Cloots R, van den Hurk K, Balint B, Murphy IG, McDermott EW, Sheahan K, Jirström K, Nodin B, Mallya-Udupi G, van den Oord JJ, Gallagher WM, Esteller M.

BMC Med. 2017 Jun 5;15(1):101. doi: 10.1186/s12916-017-0851-3.

PMID:28578692

________________________________________________________________________________________________________________________

Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer.

Zuurbier L, Rahman A, Cordes M, Scheick J, Wong TJ, Rustenburg F, Joseph JC, Dynoodt P, Casey R, Drillenburg P, Gerhards M, Barat A, Klinger R, Fender B, O’Connor DP, Betge J, Ebert MP, Gaiser T, Prehn JHM, Griffioen AW, van Grieken NCT, Ylstra B, Byrne AT, van der Flier LG, Gallagher WM, Postel R.

Oncotarget. 2017 Jun 27;8(26):42949-42961. doi: 10.18632/oncotarget.17306.

PMID:28487489

________________________________________________________________________________________________________________________

Therapeutic Rationale to Target Highly Expressed CDK7 Conferring Poor Outcomes in Triple-Negative Breast Cancer.

Li B, Ni Chonghaile T, Fan Y, Madden SF, Klinger R, O’Connor AE, Walsh L, O’Hurley G, Mallya Udupi G, Joseph J, Tarrant F, Conroy E, Gaber A, Chin SF, Bardwell HA, Provenzano E, Crown J, Dubois T, Linn S, Jirstrom K, Caldas C, O’Connor DP, Gallagher WM.

Cancer Res. 2017 Jul 15;77(14):3834-3845. doi: 10.1158/0008-5472.CAN-16-2546. Epub 2017 Apr 28.

PMID:28455421

________________________________________________________________________________________________________________________

Master Transcriptional Regulators in Cancer: Discovery via Reverse Engineering Approaches and Subsequent Validation.

Moran B, Rahman A, Palonen K, Lanigan FT, Gallagher WM.

Cancer Res. 2017 May 1;77(9):2186-2190. doi: 10.1158/0008-5472.CAN-16-1813. Epub 2017 Apr 20. Review.

PMID:28428271

Dwane L, Gallagher WM, Ní Chonghaile T, O’Connor DP.

J Biol Chem. 2017 Mar 3;292(9):3543-3551. doi: 10.1074/jbc.R116.755694. Review.

PMID: 28154183
___________________________________________________________________________________________________________________________
The prognostic utility of the transcription factor SRF in docetaxel-resistant prostate cancer: in-vitro discovery and in-vivo validation.Lundon DJ, Boland A, Prencipe M, Hurley G, O’Neill A, Kay E, Aherne ST, Doolan P, Madden SF, Clynes M, Morrissey C, Fitzpatrick JM, Watson RW.BMC Cancer. 2017 Mar 1;17(1):163. doi: 10.1186/s12885-017-3100-4.PMID: 28249598  Free PMC Article___________________________________________________________________________________________________________________________

Vitamin D receptor as a target for breast cancer therapy.

Murray A, Madden S, Synnott NC, Klinger R, O’Connor D, O’Donovan N, Gallagher W, Crown J, Duffy M.

Endocr Relat Cancer. 2017 Feb 17. pii: ERC-16-0463. doi: 10.1530/ERC-16-0463. [Epub ahead of print]

PMID: 28213567
___________________________________________________________________________________________________________________________

Comparative analysis of prostate-specific antigen by two-dimensional gel electrophoresis and capillary electrophoresis.

Barrabés S, Farina-Gomez N, Llop E, Puerta A, Diez-Masa JC, Perry A, de Llorens R, de Frutos M, Peracaula R.

Electrophoresis. 2017 Feb;38(3-4):408-416. doi: 10.1002/elps.201600432.

PMID: 27696472
___________________________________________________________________________________________________________________________

O’Farrell AC, Evans R, Silvola JM, Miller IS, Conroy E, Hector S, Cary M, Murray DW, Jarzabek MA, Maratha A, Alamanou M, Udupi GM, Shiels L, Pallaud C, Saraste A, Liljenbäck H, Jauhiainen M, Oikonen V, Ducret A, Cutler P, McAuliffe FM, Rousseau JA, Lecomte R, Gascon S, Arany Z, Ky B, Force T, Knuuti J, Gallagher WM, Roivainen A, Byrne AT.

PLoS One. 2017 Jan 27;12(1):e0169964. doi: 10.1371/journal.pone.0169964.

PMID:28129334 Free PMC Article
___________________________________________________________________________________________________________________________

O’Brien KP, Ramphul E, Howard L, Gallagher WM, Malone C, Kerin MJ, Dwyer RM.

Methods Mol Biol. 2017;1509:123-139.

PMID: 27826923
___________________________________________________________________________________________________________________________

Mulrane L, Gallagher WM, O’Connor DP.

Methods Mol Biol. 2017;1501:311-325.

PMID: 27796961
___________________________________________________________________________________________________________________________

Synnott NC, Murray A, McGowan PM, Kiely M, Kiely PA, O’Donovan N, O’Connor DP,Gallagher WM, Crown J, Duffy MJ.

Int J Cancer. 2017 Jan 1;140(1):234-246. doi: 10.1002/ijc.30425.

PMID: 27615392
___________________________________________________________________________________________________________________________

The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer.

Toomey S, Madden SF, Furney SJ, Fan Y, McCormack M, Stapleton C, Cremona M, Cavalleri GL, Milewska M, Elster N, Carr A, Fay J, Kay EW, Kennedy S, Crown J,Gallagher WM, Hennessy BT, Eustace AJ.

Oncotarget. 2016 Nov 15;7(46):75518-75525. doi: 10.18632/oncotarget.12782.

PMID: 27776352 Free Article
___________________________________________________________________________________________________________________________

Mulvaney EP, Shilling C, Eivers SB, Perry AS, Bjartell A, Kay EW, Watson RW, Kinsella BT.

Oncotarget. 2016 Nov 8;7(45):73171-73187. doi: 10.18632/oncotarget.12256.

PMID: 27689401 Free Article
___________________________________________________________________________________________________________________________

Murphy AG, Casey R, Maguire A, Tosetto M, Butler CT, Conroy E, Reynolds AL, Sheahan K, O’Donoghue D, Gallagher WM, Fennelly D, Kennedy BN, O’Sullivan J.

Sci Rep. 2016 Oct 14;6:34523. doi: 10.1038/srep34523.

PMID: 27739445 Free PMC Article
___________________________________________________________________________________________________________________________

Evaluation of Cysteinyl Leukotriene Signaling as a Therapeutic Target for Colorectal Cancer.

Burke L, Butler CT, Murphy A, Moran B, Gallagher WM, O’Sullivan J, Kennedy BN.

Front Cell Dev Biol. 2016 Sep 21;4:103. Review.

PMID: 27709113 Free PMC Article
___________________________________________________________________________________________________________________________

De novo post-diagnosis statin use, breast cancer-specific and overall mortality in women with stage I-III breast cancer.

Smith A, Murphy L, Sharp L, O’Connor D, Gallagher WM, Bennett K, Barron TI.

Br J Cancer. 2016 Aug 23;115(5):592-8. doi: 10.1038/bjc.2016.232.

PMID: 27482648
___________________________________________________________________________________________________________________________

Diagnostic and Therapeutic Implications of Histone Epigenetic Modulators in Breast Cancer.

Walsh L, Gallagher WM, O’Connor DP, Ní Chonghaile T.

Expert Rev Mol Diagn. 2016;16(5):541-51. doi: 10.1586/14737159.2016.1156534. Review.

PMID: 26895288
___________________________________________________________________________________________________________________________

Lysosome triggered near-infrared fluorescence imaging of cellular trafficking processes in real time.

Grossi M, Morgunova M, Cheung S, Scholz D, Conroy E, Terrile M, Panarella A, Simpson JC, Gallagher WM, O’Shea DF.

Nat Commun. 2016 Mar 1;7:10855. doi: 10.1038/ncomms10855.

PMID: 26927507 Free PMC Article
___________________________________________________________________________________________________________________________

Improving multivariable prostate cancer risk assessment using the Prostate Health Index.

Foley RW, Gorman L, Sharifi N, Murphy K, Moore H, Tuzova AV, Perry AS, Murphy TB, Lundon DJ, Watson RW.

BJU Int. 2016 Mar;117(3):409-17. doi: 10.1111/bju.13143.

PMID: 25847734 Free Article
___________________________________________________________________________________________________________________________

Integration of genomic, transcriptomic and proteomic data identifies two biologically distinct subtypes of invasive lobular breast cancer.

Michaut M, Chin SF, Majewski I, Severson TM, Bismeijer T, de Koning L, Peeters JK, Schouten PC, Rueda OM, Bosma AJ, Tarrant F, Fan Y, He B, Xue Z, Mittempergher L, Kluin RJ, Heijmans J, Snel M, Pereira B, Schlicker A, Provenzano E, Ali HR, Gaber A, O’Hurley G, Lehn S, Muris JJ, Wesseling J, Kay E, Sammut SJ, Bardwell HA, Barbet AS, Bard F, Lecerf C, O’Connor DP, Vis DJ, Benes CH, McDermott U, Garnett MJ, Simon IM, Jirström K, Dubois T, Linn SC, Gallagher WM, Wessels LF, Caldas C, Bernards R.

Sci Rep. 2016 Jan 5;6:18517. doi: 10.1038/srep18517.

PMID: 26729235 Free PMC Article
___________________________________________________________________________________________________________________________

Foth M, Wouters J, de Chaumont C, Dynoodt P, Gallagher WM.

Expert Rev Mol Diagn. 2016;16(2):223-37. doi: 10.1586/14737159.2016.1126511. Review.

PMID: 26620320
___________________________________________________________________________________________________________________________

Perry AS, Baird AM, Gray SG.

Methods Mol Biol. 2015;1326:131-58. doi: 10.1007/978-1-4939-2839-2_13.

PMID: 26498619
___________________________________________________________________________________________________________________________

O’Callaghan DS, Rexhepaj E, Gately K, Coate L, Delaney D, O’Donnell DM, Kay E, O’Connell F, Gallagher WM, O’Byrne KJ.

Eur Respir J. 2015 Dec;46(6):1762-72. doi: 10.1183/13993003.00176-2014.

PMID:26541534

___________________________________________________________________________________________________________________________

Relationship between serum response factor and androgen receptor in prostate cancer.

Prencipe M, O’Neill A, O’Hurley G, Nguyen LK, Fabre A, Bjartell A, Gallagher WM, Morrissey C, Kay EW, Watson RW.

Prostate. 2015 Nov;75(15):1704-17. doi: 10.1002/pros.23051.

PMID:26250344 Free PMC Article

miR-134 in extracellular vesicles reduces triple-negative breast cancer aggression and increases drug sensitivity.

O’Brien K, Lowry MC, Corcoran C, Martinez VG, Daly M, Rani S, Gallagher WM, Radomski MW, MacLeod RA, O’Driscoll L.

Oncotarget. 2015 Oct 20;6(32):32774-89. doi: 10.18632/oncotarget.5192.

PMID:26416415 Free PMC Article
__________________________________________________________________________________________________________________________

Delineating transcriptional networks of prognostic gene signatures refines treatment recommendations for lymph node-negative breast cancer patients.

Lanigan F, Brien GL, Fan Y, Madden SF, Jerman E, Maratha A, Aloraifi F, Hokamp K, Dunne EJ, Lohan AJ, Flanagan L, Garbe JC, Stampfer MR, Fridberg M, Jirstrom K, Quinn CM, Loftus B, Gallagher WM, Geraghty J, Bracken AP.

FEBS J. 2015 Sep;282(18):3455-73. doi: 10.1111/febs.13354.

PMID: 26094870 Free Article
___________________________________________________________________________________________________________________________

Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer.

O’Hurley G, Busch C, Fagerberg L, Hallström BM, Stadler C, Tolf A, Lundberg E, Schwenk JM, Jirström K, Bjartell A, Gallagher WM, Uhlén M, Pontén F.

PLoS One. 2015 Aug 3;10(8):e0133449. doi: 10.1371/journal.pone.0133449.

PMID: 26237329 Free PMC Article
 ___________________________________________________________________________________________________________________________

The chain length of biologically produced (R)-3-hydroxyalkanoic acid affects biological activity and structure of anti-cancer peptides.

Szwej E, Devocelle M, Kenny S, Guzik M, O’Connor S, Nikodinovic-Runic J, Radivojevic J, Maslak V, Byrne AT, Gallagher WM, Zulian QR, Zinn M, O’Connor KE.

J Biotechnol. 2015 Jun 20;204:7-12. doi: 10.1016/j.jbiotec.2015.02.036.

PMID: 25820126
___________________________________________________________________________________________________________________________

High-throughput oncogene mutation profiling shows demographic differences in BRAF mutation rates among melanoma patients.

van den Hurk K, Balint B, Toomey S, O’Leary PC, Unwin L, Sheahan K, McDermott EW, Murphy I, van den Oord JJ, Rafferty M, FitzGerald DM, Moran J, Cummins R, MacEneaney O, Kay EW, O’Brien CP, Finn SP, Heffron CC, Murphy M, Yela R, Power DG, Regan PJ, McDermott CM, O’Keeffe A, Orosz Z, Donnellan PP, Crown JP, Hennessy BT, Gallagher WM.

Melanoma Res. 2015 Jun;25(3):189-99. doi: 10.1097/CMR.0000000000000149.

___________________________________________________________________________________________________________________________

Commercialized biomarkers: new horizons in prostate cancer diagnostics.

Murphy L, Prencipe M, Gallagher WM, Watson RW.

Expert Rev Mol Diagn. 2015 Apr;15(4):491-503. doi: 10.1586/14737159.2015.1011622. Review.

PMID: 25711191

___________________________________________________________________________________________________________________________

Interrogation of gossypol therapy in glioblastoma implementing cell line and patient-derived tumour models.

Jarzabek MA, Amberger-Murphy V, Callanan JJ, Gao C, Zagozdzon AM, Shiels L, Wang J, Ligon KL, Rich BE, Dicker P, Gallagher WM, Prehn JH, Byrne AT.

Br J Cancer. 2014 Dec 9;111(12):2275-86. doi: 10.1038/bjc.2014.529.

PMID: 25375271 Free PMC Article
___________________________________________________________________________________________________________________________

Identification of a ZEB2-MITF-ZEB1 transcriptional network that controls melanogenesis and melanoma progression.

Denecker G, Vandamme N, Akay O, Koludrovic D, Taminau J, Lemeire K, Gheldof A, De Craene B, Van Gele M, Brochez L, Udupi GM, Rafferty M, Balint B, Gallagher WM, Ghanem G, Huylebroeck D, Haigh J, van den Oord J, Larue L, Davidson I, Marine JC, Berx G.

Cell Death Differ. 2014 Aug;21(8):1250-61. doi: 10.1038/cdd.2014.44. Epub 2014 Apr 25.

PMID: 24769727 [PubMed – in process] Related citations
___________________________________________________________________________________________________________________________

Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.

O Leary PC, Terrile M, Bajor M, Gaj P, Hennessy BT, Mills GB, Zagozdzon A, O Connor DP, Brennan DJ, Connor K, Li J, Gonzalez-Angulo AM, Sun HD, Pu JX, Pontén F, Uhlén M, Jirström K, Nowis DA, Crown JP, Zagozdzon R, Gallagher WM.

Breast Cancer Res. 2014 Jul 10;16(4):R79. [Epub ahead of print]

PMID: 25011585 [PubMed – as supplied by publisher] Related citations
___________________________________________________________________________________________________________________________

Garbage in, garbage out: A critical evaluation of strategies used for validation of immunohistochemical biomarkers.

O’Hurley G, Sjöstedt E, Rahman A, Li B, Kampf C, Pontén F, Gallagher WM, Lindskog C.

Mol Oncol. 2014 Jun;8(4):783-798. doi: 10.1016/j.molonc.2014.03.008. Epub 2014 Mar 21. Review.

PMID: 24725481 [PubMed – as supplied by publisher] Free Article Related citations
___________________________________________________________________________________________________________________________

microRNAs: a new class of breast cancer biomarkers.

Mulrane L, Klinger R, McGee SF, Gallagher WM, O’Connor DP.

Expert Rev Mol Diagn. 2014 Apr;14(3):347-63. doi: 10.1586/14737159.2014.901153.

PMID: 24649821 [PubMed – in process] Related citations

___________________________________________________________________________________________________________________________

Noncoding RNAs in prostate cancer: the long and the short of it.

Bolton EM, Tuzova AV, Walsh AL, Lynch T, Perry AS.

Clin Cancer Res. 2014 Jan 1;20(1):35-43. doi: 10.1158/1078-0432.CCR-13-1989. Review.

PMID: 24146262 Free Article

___________________________________________________________________________________________________________________________

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Dos Santos Silva I, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O’Connor JP, O’Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92.

PMID: 24286369 [PubMed – as supplied by publisher]Related citations
___________________________________________________________________________________________________________________________

MetSizeR: selecting the optimal sample size for metabolomic studies using an analysis based approach.

Nyamundanda G, Gormley IC, Fan Y, Gallagher WM, Brennan L.

BMC Bioinformatics. 2013 Nov 21;14:338. doi: 10.1186/1471-2105-14-338.

PMID: 24261687 [PubMed – in process] Free Article Related citations
___________________________________________________________________________________________________________________________

miRNA Dysregulation in Breast Cancer.

Mulrane L, McGee SF, Gallagher WM, O’Connor DP.

Cancer Res. 2013 Nov 15;73(22):6554-62. doi: 10.1158/0008-5472.CAN-13-1841. Epub 2013 Nov 7.

PMID: 24204025 [PubMed – in process] Related citations
___________________________________________________________________________________________________________________________

Investigation of molecular alterations of AKT-3 in triple-negative breast cancer.

O’Hurley G, Daly E, O’Grady A, Cummins R, Quinn C, Flanagan L, Pierce A, Fan Y, Lynn MA, Rafferty M, Fitzgerald D, Pontén F, Duffy MJ, Jirström K, Kay EW, Gallagher WM.

Histopathology. 2013 Oct 19. doi: 10.1111/his.12313. [Epub ahead of print]

PMID: 24138071 [PubMed – as supplied by publisher] Related citations
___________________________________________________________________________________________________________________________

BreastMark: an integrated approach to mining publicly available transcriptomic datasets relating to breast cancer outcome.

Madden SF, Clarke C, Aherne ST, Gaule P, O’Donovan N, Crown J, Clynes M, Gallagher WM.

Breast Cancer Res. 2013 Jul 2;15(4):R52. [Epub ahead of print] PMID: 23820017 [PubMed – as supplied by publisher] Related citations

___________________________________________________________________________________________________________________________

Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis.

Clarke C, Madden SF, Doolan P, Aherne ST, Joyce H, O’Driscoll L, Gallagher WM, Hennessy BT, Moriarty M, Crown J, Kennedy S, Clynes M.

Carcinogenesis. 2013 Jul 8. [Epub ahead of print] PMID: 23740839 [PubMed – as supplied by publisher] Related citations

___________________________________________________________________________________________________________________________

A texture based pattern recognition approach to distinguish melanoma from non-melanoma cells in histopathological tissue microarray sections.

Rexhepaj E, Agnarsdóttir M, Bergman J, Edqvist PH, Bergqvist M, Uhlén M, Gallagher WM, Lundberg E, Ponten F.

PLoS One. 2013 May 17;8(5):e62070. doi: 10.1371/journal.pone.0062070. Print 2013. PMID: 23690928 [PubMed – in process] Free PMC Article Related citations

___________________________________________________________________________________________________________________________

Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer.

O Leary PC, Penny S, Dolan RT, Kelly CM, Madden SF, Rexhepaj E, Brennan DJ, McCann AH, Pontén F, Uhlén M, Zagozdzon R, Duffy MJ, Kell MR, Jirström K, Gallagher WM.

BMC Cancer. 2013 Apr 2;13(1):175. [Epub ahead of print] PMID: 23547718 [PubMed – as supplied by publisher] Related citations

___________________________________________________________________________________________________________________________

Identification of transcription factors associated with castration-resistance: Is the serum responsive factor a potential therapeutic target?

Prencipe M, Madden SF, O’Neill A, O’Hurley G, Culhane A, O’Connor D, Klocker H, Kay EW,Gallagher WM, Watson WR.

Prostate. 2013 May;73(7):743-53. doi: 10.1002/pros.22618. Epub 2013 Jan 28. PMID: 23359479 [PubMed – in process] Related citations

___________________________________________________________________________________________________________________________

The anti-cancer activity of a cationic anti-microbial peptide derived from monomers of polyhydroxyalkanoate.

O’Connor S, Szwej E, Nikodinovic-Runic J, O’Connor A, Byrne AT, Devocelle M, O’Donovan N,Gallagher WM, Babu R, Kenny ST, Zinn M, Zulian QR, O’Connor KE.

Biomaterials. 2013 Apr;34(11):2710-8. doi: 10.1016/j.biomaterials.2012.12.032. Epub 2013 Jan 21. PMID: 23343631 [PubMed – in process] Related citations

___________________________________________________________________________________________________________________________

Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses.

Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, Hewitt S, Udupi GM, Gallagher WM, Wegner C, West BL, Wang-Gillam A, Goedegebuure P, Linehan DC, DeNardo DG.

Cancer Res. 2013 Feb 1;73(3):1128-41. doi: 10.1158/0008-5472.CAN-12-2731. Epub 2012 Dec 5. PMID: 23221383 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

miR-187 is an independent prognostic factor in breast cancer and confers increased invasive potential in vitro.

Mulrane L, Madden SF, Brennan DJ, Gremel G, McGee SF, McNally S, Martin F, Crown JP, Jirström K, Higgins DG, Gallagher WM, O’Connor DP.

Clin Cancer Res. 2012 Dec 15;18(24):6702-13. doi: 10.1158/1078-0432.CCR-12-1420. Epub 2012 Oct 11. PMID: 23060431 [PubMed – in process] Related citations

___________________________________________________________________________________________________________________________

Tumor profiling using protein biomarker panels in malignant melanoma: application of tissue microarrays and beyond.

Joyce CW, Murphy IG, Rafferty M, Ryan D, McDermott EW, Gallagher WM.

Expert Rev Proteomics. 2012 Aug;9(4):415-23. doi: 10.1586/epr.12.5. Review. PMID: 22967078 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Focus on cancer proteomics.

Collins BC, Gallagher WM.

Proteomics. 2012 Jul;12(13):2065-6. doi: 10.1002/pmic.201270084. No abstract available. PMID: 22807453 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice.

Zagozdzon AM, O’Leary P, Callanan JJ, Crown J, Gallagher WM, Zagozdzon R.

BMC Cancer. 2012 May 30;12:209. doi: 10.1186/1471-2407-12-209. PMID: 22646761 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Development of a pharmaceutical hepatotoxicity biomarker panel using a discovery to targeted proteomics approach.

Collins BC, Miller CA, Sposny A, Hewitt P, Wells M, Gallagher WM, Pennington SR.

Mol Cell Proteomics. 2012 Aug;11(8):394-410. doi: 10.1074/mcp.M111.016493. Epub 2012 Apr 23. PMID: 22527513 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Proteomic portrait of human breast cancer progression identifies novel prognostic markers.

Geiger T, Madden SF, Gallagher WM, Cox J, Mann M.

Cancer Res. 2012 May 1;72(9):2428-39. doi: 10.1158/0008-5472.CAN-11-3711. Epub 2012 Mar 13. PMID: 22414580 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

The cocaine- and amphetamine-regulated transcript mediates ligand-independent activation of ERα, and is an independent prognostic factor in node-negative breast cancer.

Brennan DJ, O’Connor DP, Laursen H, McGee SF, McCarthy S, Zagozdzon R, Rexhepaj E, Culhane AC, Martin FM, Duffy MJ, Landberg G, Ryden L, Hewitt SM, Kuhar MJ, Bernards R, Millikan RC, Crown JP, Jirström K, Gallagher WM.

Oncogene. 2012 Jul 26;31(30):3483-94. doi: 10.1038/onc.2011.519. Epub 2011 Dec 5. PMID: 22139072 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Identification of cell surface-specific markers to target human nucleus pulposus cells: expression of carbonic anhydrase XII varies with age and degeneration.

Power KA, Grad S, Rutges JP, Creemers LB, van Rijen MH, O’Gaora P, Wall JG, Alini M, Pandit A, Gallagher WM.

Arthritis Rheum. 2011 Dec;63(12):3876-86. doi: 10.1002/art.30607. PMID: 22127705 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

P-Rex1 is required for efficient melanoblast migration and melanoma metastasis.

Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL, Timpson P, Li A, Cammareri P, Ridgway RA, Morton JP, Doyle B, Hegarty S, Rafferty M, Murphy IG, McDermott EW, Sheahan K, Pedone K, Finn AJ, Groben PA, Thomas NE, Hao H, Carson C, Norman JC, Machesky LM,Gallagher WM, Jackson IJ, Van Kempen L, Beermann F, Der C, Larue L, Welch HC, Ozanne BW, Sansom OJ.

Nat Commun. 2011 Nov 22;2:555. doi: 10.1038/ncomms1560. PMID: 22109529 [PubMed – indexed for MEDLINE] Related citations

_______________________________________________________________________________________________________________________

A dynamic inflammatory cytokine network in the human ovarian cancer microenvironment.

Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L; Australian Ovarian Cancer Study Group, Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill FR.

Cancer Res. 2012 Jan 1;72(1):66-75. doi: 10.1158/0008-5472.CAN-11-2178. Epub 2011 Nov 7. PMID: 22065722 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy.

DeNardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL, Madden SF, Gallagher WM, Wadhwani N, Keil SD, Junaid SA, Rugo HS, Hwang ES, Jirström K, West BL, Coussens LM.

Cancer Discov. 2011 Jun;1(1):54-67. doi: 10.1158/2159-8274.CD-10-0028. Epub 2011 Jun 1. PMID: 22039576 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Serum proteomic profiling reveals that pretreatment complement protein levels are predictive of esophageal cancer patient response to neoadjuvant chemoradiation.

Maher SG, McDowell DT, Collins BC, Muldoon C, Gallagher WM, Reynolds JV.

Ann Surg. 2011 Nov;254(5):809-16; discussion 816-7. doi: 10.1097/SLA.0b013e31823699f2. PMID: 22005152 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Characterisation and manipulation of docetaxel resistant prostate cancer cell lines.

O’Neill AJ, Prencipe M, Dowling C, Fan Y, Mulrane L, Gallagher WM, O’Connor D, O’Connor R, Devery A, Corcoran C, Rani S, O’Driscoll L, Fitzpatrick JM, Watson RW.

Mol Cancer. 2011 Oct 7;10:126. doi: 10.1186/1476-4598-10-126. PMID: 21982118 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation.

Sernbo S, Gustavsson E, Brennan DJ, Gallagher WM, Rexhepaj E, Rydnert F, Jirström K, Borrebaeck CA, Ek S.

BMC Cancer. 2011 Sep 24;11:405. doi: 10.1186/1471-2407-11-405. PMID: 21943380 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by b1 cells.

Hams E, Saunders SP, Cummins EP, O’Connor A, Tambuwala MT, Gallagher WM, Byrne A, Campos-Torres A, Moynagh PM, Jobin C, Taylor CT, Fallon PG.

Shock. 2011 Sep;36(3):295-302. PMID: 21844787 [PubMed – in process] Related citations

___________________________________________________________________________________________________________________________

Interleukin-6 as a therapeutic target in human ovarian cancer.

Coward J, Kulbe H, Chakravarty P, Leader DA, Vassileva V, Leinster DA, Thompson R, Schioppa T, Nemeth JA, Vermeulin J, Singh N, Avril NE, Cummings J, Rexhepaj E, Jirstrom K, Gallagher WM, Brennan DJ, McNeish IA, Balkwill FR.

Clin Cancer Res. 2011 Jul 27. [Epub ahead of print] PMID: 21795409 [PubMed – as supplied by publisher] Related citations

___________________________________________________________________________________________________________________________

Examining the role of Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach.

Vader P, van der Meel R, Symons MH, Fens MH, Pieters E, Wilschut KJ, Storm G, Jarzabek M, Gallagher WM, Schiffelers RM, Byrne AT.

Angiogenesis. 2011 Jul 26. [Epub ahead of print] PMID: 21789714 [PubMed – as supplied by publisher] Related citations

___________________________________________________________________________________________________________________________

Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma.

Gremel G, Ryan D, Rafferty M, Lanigan F, Hegarty S, Lavelle M, Murphy I, Unwin L, Joyce C, Faller W, McDermott EW, Sheahan K, Ponten F, Gallagher WM.

Br J Cancer. 2011 Aug 9;105(4):565-74. doi: 10.1038/bjc.2011.249. Epub 2011 Jul 5. PMID: 21730974 [PubMed – in process] Related citations

___________________________________________________________________________________________________________________________

Truncated HER2: implications for HER2-targeted therapeutics.

Zagozdzon R, Gallagher WM, Crown J.

Drug Discov Today. 2011 Jun 16. [Epub ahead of print] PMID: 21704182 [PubMed – as supplied by publisher] Related citations

___________________________________________________________________________________________________________________________

SATB2 in combination with cytokeratin 20 identifies over 95% of all colorectal carcinomas.

Magnusson K, de Wit M, Brennan DJ, Johnson LB, McGee SF, Lundberg E, Naicker K, Klinger R, Kampf C, Asplund A, Wester K, Gry M, Bjartell A, Gallagher WM, Rexhepaj E, Kilpinen S, Kallioniemi OP, Belt E, Goos J, Meijer G, Birgisson H, Glimelius B, Borrebaeck CA, Navani S, Uhlén M, O’Connor DP, Jirström K, Pontén F.

Am J Surg Pathol. 2011 Jul;35(7):937-48. PMID: 21677534 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

The emerging role of FK506-binding proteins as cancer biomarkers: a focus on FKBPL.

McKeen HD, Brennan DJ, Hegarty S, Lanigan F, Jirstrom K, Byrne C, Yakkundi A, McCarthy HO, Gallagher WM, Robson T.

Biochem Soc Trans. 2011 Apr 1;39(2):663-8. Review. PMID: 21428958 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Mechanism of cell death mediated by a BF(2) -chelated tetraryl-azadipyrromethene photodynamic therapeutic: Dissection of the apoptotic pathway in vitro and in vivo.

O’Connor AE, McGee MM, Likar Y, Ponomarev V, Callanan JJ, O’shea DF, Byrne AT, Gallagher WM.

Int J Cancer. 2011 Mar 16. doi: 10.1002/ijc.26073. [Epub ahead of print] PMID: 21413012 [PubMed – as supplied by publisher] Related citations

___________________________________________________________________________________________________________________________

Standardization of Models and Methods Used to Assess Nanoparticles in Cardiovascular Applications.

Fitzgerald KT, Holladay CA, McCarthy C, Power KA, Pandit A, Gallagher WM.

Small. 2011 Feb 11. doi: 10.1002/smll.201001347. [Epub ahead of print] PMID: 21319299 [PubMed – as supplied by publisher] Related citations

___________________________________________________________________________________________________________________________

Brennan DJ, Laursen H, O’Connor DP, Borgquist S, Uhlen M, Gallagher WM, Pontén F, Millikan RC, Rydén L, Jirström K.

Breast Cancer Res. 2011 Jan 31;13(1):R12. [Epub ahead of print] PMID: 21281480 [PubMed – as supplied by publisher] Related citations

___________________________________________________________________________________________________________________________

Functionalized Scaffold-mediated Interleukin 10 Gene Delivery Significantly Improves Survival Rates of Stem Cells In Vivo.

Holladay C, Power K, Sefton M, O’Brien T, Gallagher WM, Pandit A.

Mol Ther. 2011 Jan 25. [Epub ahead of print] PMID: 21266957 [PubMed – as supplied by publisher] Related citations

___________________________________________________________________________________________________________________________

The VEGF/Rho GTPase signalling pathway: A promising target for anti-angiogenic/anti-invasion therapy.

van der Meel R, Symons MH, Kudernatsch R, Kok RJ, Schiffelers RM, Storm G, Gallagher WM, Byrne AT.

Drug Discov Today. 2011 Mar;16(5-6):219-28. Epub 2011 Jan 22. PMID: 21262381 [PubMed – in process] Related citations

___________________________________________________________________________________________________________________________

Evaluation of the prognostic significance of MSMB and CRISP3 in prostate cancer using automated image analysis.

Dahlman A, Rexhepaj E, Brennan DJ, Gallagher WM, Gaber A, Lindgren A, Jirström K, Bjartell A.

Mod Pathol. 2011 Jan 14. [Epub ahead of print] PMID: 21240253 [PubMed – as supplied by publisher] Related citations

___________________________________________________________________________________________________________________________

Dasari S, Chambers MC, Codreanu SG, Liebler DC, Collins BC, Pennington SR, Gallagher WM, Tabb DL.

Chem Res Toxicol. 2011 Feb 18;24(2):204-16. Epub 2011 Jan 7. PMID: 21214251 [PubMed – in process] Related citations

___________________________________________________________________________________________________________________________

Early proteomic analysis may allow noninvasive identification of hepatitis C response to treatment with pegylated interferon α-2b and ribavirin.

Devitt EJ, Power KA, Lawless MW, Browne JA, Gaora PO, Gallagher WM, Crowe J.

Eur J Gastroenterol Hepatol. 2011 Feb;23(2):177-83. PMID: 21164346 [PubMed – in process] Related citations

___________________________________________________________________________________________________________________________

Fitzpatrick SF, Tambuwala MM, Bruning U, Schaible B, Scholz CC, Byrne A, O’Connor A, Gallagher WM, Lenihan CR, Garvey JF, Howell K, Fallon PG, Cummins EP, Taylor CT.

J Immunol. 2011 Jan 15;186(2):1091-6. Epub 2010 Dec 13. PMID: 21149600 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Gallagher WM.

Proteomics Clin Appl. 2010 Jul;4(6-7):577-8. doi: 10.1002/prca.201090020. No abstract available. PMID: 21137075 [PubMed – in process] Related citations

___________________________________________________________________________________________________________________________

Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer.

Rexhepaj E, Jirstrom K, O’Connor DP, O’Brien SL, Landberg G, Duffy MJ, Brennan DJ, Gallagher WM.

BMC Cancer. 2010 Nov 23;10:639. PMID: 21092276 [PubMed – in process] Free PMC Article Free full text Related citations

___________________________________________________________________________________________________________________________

Lau TY, Collins BC, Stone P, Tang N, Gallagher WM, Pennington SR.

Methods Mol Biol. 2011;691:417-27. PMID: 20972768 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Collins BC, Lau TY, Pennington SR, Gallagher WM.

Methods Mol Biol. 2011;691:369-83. PMID: 20972766 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Ryan D, Mulrane L, Rexhepaj E, Gallagher WM.

Methods Mol Biol. 2011;691:97-112. PMID: 20972749 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Ursini-Siegel J, Cory S, Zuo D, Hardy WR, Rexhepaj E, Lam S, Schade B, Jirstrom K, Bjur E, Piccirillo CA, Denardo D, Coussens LM, Brennan DJ, Gallagher WM, Park M, Pawson T, Hallett M, Muller WJ.

Cancer Res. 2010 Oct 15;70(20):7776-87. Epub 2010 Oct 5. PMID: 20924104 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Agnarsdóttir M, Sooman L, Bolander A, Strömberg S, Rexhepaj E, Bergqvist M, Ponten F, Gallagher W, Lennartsson J, Ekman S, Uhlen M, Hedstrand H.

Melanoma Res. 2010 Dec;20(6):468-78. PMID: 20890226 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Faller WJ, Rafferty M, Hegarty S, Gremel G, Ryan D, Fraga MF, Esteller M, Dervan PA, Gallagher WM.

Melanoma Res. 2010 Oct;20(5):392-400. PMID: 20848733 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Whyte J, Thornton L, McNally S, McCarthy S, Lanigan F, Gallagher WM, Stein T, Martin F.

J Cell Sci. 2010 Oct 1;123(Pt 19):3316-28. PMID: 20844151 [PubMed – in process] Related citations
___________________________________________________________________________________________________________________________

Brennan DJ, O’Connor DP, Rexhepaj E, Ponten F, Gallagher WM.

Nat Rev Cancer. 2010 Sep;10(9):605-17. Epub 2010 Aug 19. Review. PMID: 20720569 [PubMed – indexed for MEDLINE] Related citations
___________________________________________________________________________________________________________________________

Dash BC, Réthoré G, Monaghan M, Fitzgerald K, Gallagher W, Pandit A.

Biomaterials. 2010 Nov;31(32):8188-97. Epub 2010 Aug 10. PMID: 20701967 [PubMed – indexed for MEDLINE] Related citations

___________________________________________________________________________________________________________________________

Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro.

Lanigan F, Gremel G, Hughes R, Brennan DJ, Martin F, Jirström K, Gallagher WM.

Breast Cancer Res. 2010;12(4):R59. Epub 2010 Aug 3. PMID: 20682066 [PubMed – indexed for MEDLINE] Free full text Related citations

___________________________________________________________________________________________________________________________

Effect of Surface Wettability and Topography on the Adhesion of Osteosarcoma Cells on Plasma-modified Polystyrene.

Dowling DP, Miller IS, Ardhaoui M, Gallagher WM.

J Biomater Appl. 2010 Jun 21. [Epub ahead of print] PMID: 20566655 [PubMed – as supplied by publisher] Related citations

____________________________________________________________________________________________________________________________

Power KA, Fitzgerald KT, Gallagher WM.

Biomaterials. 2010 Sep;31(26):6667-74. Epub 2010 Jun 16. Review. PMID: 20557931 [PubMed – indexed for MEDLINE] Related citations

____________________________________________________________________________________________________________________________

Topoisomerase I Amplification in Melanoma is Associated with More Advanced Tumours and Poor Prognosis.

Ryan D, Rafferty M, Hegarty S, Leary PO, Faller W, Gremel G, Bergqvist M, Agnarsdottir M, Strömberg S, Kampf C, Pontén F, Millikan RC, Dervan PA, Gallagher WM.

Pigment Cell Melanoma Res. 2010 Apr 30. [Epub ahead of print]PMID: 20465595 [PubMed – as supplied by publisher]Related citations

___________________________________________________________________________________________________________________________

Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer.

Brennan DJ, Brändstedt J, Rexhepaj E, Foley M, Pontén F, Uhlén M, Gallagher WM, O’Connor DP, O’Herlihy C, Jirstrom K.

BMC Cancer. 2010 Apr 1;10:125.PMID: 20359358 [PubMed – in process]Free ArticleRelated citations

___________________________________________________________________________________________________________________________

O’Donovan N, Byrne AT, O’Connor AE, McGee S, Gallagher WM, Crown J.

Invest New Drugs. 2010 Mar 16. [Epub ahead of print]PMID: 20229355 [PubMed – as supplied by publisher]Related citations

___________________________________________________________________________________________________________________________

Collins BC, Sposny A, McCarthy D, Brandenburg A, Woodbury R, Pennington SR, Gautier JC, Hewitt P, Gallagher WM.

Proteomics. 2010 Apr;10(8):1592-608.PMID: 20162557 [PubMed – in process]Related citations

___________________________________________________________________________________________________________________________

van der Meel R, Gallagher WM, Oliveira S, O’Connor AE, Schiffelers RM, Byrne AT.

Drug Discov Today. 2010 Feb;15(3-4):102-14. Epub 2009 Dec 24. Review.PMID: 20035896 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Prioritization of candidate protein biomarkers from an in vitro model system of breast tumor progression toward clinical verification.

Lau TY, Power KA, Dijon S, de Gardelle I, McDonnell S, Duffy MJ, Pennington SR, Gallagher WM.

J Proteome Res. 2010 Mar 5;9(3):1450-9.PMID: 20000743 [PubMed – in process]Related citations

___________________________________________________________________________________________________________________________

O’Neill K, Lyons SK, Gallagher WM, Curran KM, Byrne AT.

J Pathol. 2010 Feb;220(3):317-27. Review.PMID: 19967724 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Strömberg S, Agnarsdóttir M, Magnusson K, Rexhepaj E, Bolander A, Lundberg E, Asplund A, Ryan D, Rafferty M, Gallagher WM, Uhlen M, Bergqvist M, Ponten F.

J Proteome Res. 2009 Apr;8(4):1639-46.PMID: 19714869 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Porphyrin and nonporphyrin photosensitizers in oncology: preclinical and clinical advances in photodynamic therapy.

O’Connor AE, Gallagher WM, Byrne AT.

Photochem Photobiol. 2009 Sep-Oct;85(5):1053-74. Epub 2009 Aug 3. Review.PMID: 19682322 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Miller IS, Lynch I, Dowling D, Dawson KA, Gallagher WM.

J Biomed Mater Res A. 2010 May;93(2):493-504.PMID: 19585567 [PubMed – in process]Related citations

___________________________________________________________________________________________________________________________

JAM-A expression positively correlates with poor prognosis in breast cancer patients.

McSherry EA, McGee SF, Jirstrom K, Doyle EM, Brennan DJ, Landberg G, Dervan PA, Hopkins AM, Gallagher WM.

Int J Cancer. 2009 Sep 15;125(6):1343-51.PMID: 19533747 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Omic profiling for drug safety assessment: current trends and public-private partnerships.

Gallagher WM, Tweats D, Koenig J.

Drug Discov Today. 2009 Apr;14(7-8):337-42.PMID: 19340928 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Identification and functional validation of therapeutic targets for malignant melanoma.

Gremel G, Rafferty M, Lau TY, Gallagher WM.

Crit Rev Oncol Hematol. 2009 Dec;72(3):194-214. Epub 2009 Mar 27. Review.PMID: 19328713 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

High-throughput proteomics detection of novel splice isoforms in human platelets.

Power KA, McRedmond JP, de Stefani A, Gallagher WM, Gaora PO.

PLoS One. 2009;4(3):e5001. Epub 2009 Mar 24.PMID: 19308253 [PubMed – indexed for MEDLINE]Free PMC ArticleFree textRelated citations

___________________________________________________________________________________________________________________________

The transcription factor Sox11 is a prognostic factor for improved recurrence-free survival in epithelial ovarian cancer.

Brennan DJ, Ek S, Doyle E, Drew T, Foley M, Flannelly G, O’Connor DP, Gallagher WM, Kilpinen S, Kallioniemi OP, Jirstrom K, O’Herlihy C, Borrebaeck CA.

Eur J Cancer. 2009 May;45(8):1510-7. Epub 2009 Mar 9.PMID: 19272768 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Selective expression of Syntaxin-7 protein in benign melanocytes and malignant melanoma.

Str Mberg S, Agnarsd Ttir MT, Magnusson K, Rexhepaj E, Bolander S, Lundberg E, Asplund A, Ryan D, Rafferty M, Gallagher W, Uhlen M, Bergqvist M, Ponten F.

J Proteome Res. 2009 Jan 28. [Epub ahead of print]PMID: 19173671 [PubMed – as supplied by publisher]Related citations

___________________________________________________________________________________________________________________________

Increased claudin-4 expression is associated with poor prognosis and high tumour grade in breast cancer.

Lanigan F, McKiernan E, Brennan DJ, Hegarty S, Millikan RC, McBryan J, Jirstrom K, Landberg G, Martin F, Duffy MJ, Gallagher WM.

Int J Cancer. 2009 May 1;124(9):2088-97.PMID: 19142967 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Automated image analysis in histopathology: a valuable tool in medical diagnostics.

Mulrane L, Rexhepaj E, Penney S, Callanan JJ, Gallagher WM.

Expert Rev Mol Diagn. 2008 Nov;8(6):707-25. Review.PMID: 18999923 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer.

Rexhepaj E, Brennan DJ, Holloway P, Kay EW, McCann AH, Landberg G, Duffy MJ, Jirstrom K, Gallagher WM.

Breast Cancer Res. 2008;10(5):R89. Epub 2008 Oct 23.PMID: 18947395 [PubMed – indexed for MEDLINE]Free PMC ArticleFree textRelated citations

___________________________________________________________________________________________________________________________

A microRNA DNA methylation signature for human cancer metastasis.

Lujambio A, Calin GA, Villanueva A, Ropero S, Sánchez-Céspedes M, Blanco D, Montuenga LM, Rossi S, Nicoloso MS, Faller WJ, Gallagher WM, Eccles SA, Croce CM, Esteller M.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13556-61. Epub 2008 Sep 3.PMID: 18768788 [PubMed – indexed for MEDLINE]Free PMC ArticleFree textRelated citations

___________________________________________________________________________________________________________________________

Creation of a digital slide and tissue microarray resource from a multi-institutional predictive toxicology study in the rat: an initial report from the PredTox group.

Mulrane L, Rexhepaj E, Smart V, Callanan JJ, Orhan D, Eldem T, Mally A, Schroeder S, Meyer K, Wendt M, O’Shea D, Gallagher WM.

Exp Toxicol Pathol. 2008 Aug;60(4-5):235-45. Epub 2008 May 13.PMID: 18479893 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Altered cytoplasmic-to-nuclear ratio of survivin is a prognostic indicator in breast cancer.

Brennan DJ, Rexhepaj E, O’Brien SL, McSherry E, O’Connor DP, Fagan A, Culhane AC, Higgins DG, Jirstrom K, Millikan RC, Landberg G, Duffy MJ, Hewitt SM, Gallagher WM.

Clin Cancer Res. 2008 May 1;14(9):2681-9.PMID: 18451232 [PubMed – indexed for MEDLINE]Free ArticleRelated citations

___________________________________________________________________________________________________________________________

Prognostic ability of a panel of immunohistochemistry markers – retailoring of an ‘old solution’.

Brennan DJ, Gallagher WM.

Breast Cancer Res. 2008;10(1):102. Epub 2008 Feb 25.PMID: 18331621 [PubMed – indexed for MEDLINE]Free PMC ArticleFree textRelated citations

___________________________________________________________________________________________________________________________

Use of proteomics for the discovery of early markers of drug toxicity.

Collins BC, Clarke A, Kitteringham NR, Gallagher WM, Pennington SR.

Expert Opin Drug Metab Toxicol. 2007 Oct;3(5):689-704. Review.PMID: 17916055 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Contribution of DNA and tissue microarray technology to the identification and validation of biomarkers and personalised medicine in breast cancer.

Brennan DJ, Kelly C, Rexhepaj E, Dervan PA, Duffy MJ, Gallagher WM.

Cancer Genomics Proteomics. 2007 May-Jun;4(3):121-34. Review.PMID: 17878516 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

DNA microarray-based transcriptomic profiling of an isogenic cell culture model of breast tumour cell invasion.

Hughes L, O’Brien SL, Gallagher WM, Mcdonnell S.

Anticancer Res. 2007 May-Jun;27(3A):1353-9.PMID: 17593630 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Real-time quantitative reverse transcriptase-polymerase chain reaction analysis of melanoma progression-associated genes.

Rafferty M, Faller WJ, Moss C, McCormack J, Mãlandsmo GM, Easty DJ, Gallagher WM.

Anticancer Res. 2007 May-Jun;27(3A):1301-7.PMID: 17593623 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Survivin: a promising tumor biomarker.

Duffy MJ, O’Donovan N, Brennan DJ, Gallagher WM, Ryan BM.

Cancer Lett. 2007 Apr 28;249(1):49-60. Epub 2007 Feb 1. Review.PMID: 17275177 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Breast cancer proteomics: clinical perspectives.

Lau TY, O’Connor DP, Brennan DJ, Duffy MJ, Pennington SR, Gallagher WM.

Expert Opin Biol Ther. 2007 Feb;7(2):209-19. Review.PMID: 17250459 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Combination of SELDI-TOF-MS and data mining provides early-stage response prediction for rectal tumors undergoing multimodal neoadjuvant therapy.

Smith FM, Gallagher WM, Fox E, Stephens RB, Rexhepaj E, Petricoin EF 3rd, Liotta L, Kennedy MJ, Reynolds JV.

Ann Surg. 2007 Feb;245(2):259-66.PMID: 17245180 [PubMed – indexed for MEDLINE]Free PMC ArticleFree textRelated citations

___________________________________________________________________________________________________________________________

CENP-F expression is associated with poor prognosis and chromosomal instability in patients with primary breast cancer.

O’Brien SL, Fagan A, Fox EJ, Millikan RC, Culhane AC, Brennan DJ, McCann AH, Hegarty S, Moyna S, Duffy MJ, Higgins DG, Jirström K, Landberg G, Gallagher WM.

Int J Cancer. 2007 Apr 1;120(7):1434-43.PMID: 17205517 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

CA IX is an independent prognostic marker in premenopausal breast cancer patients with one to three positive lymph nodes and a putative marker of radiation resistance.

Brennan DJ, Jirstrom K, Kronblad A, Millikan RC, Landberg G, Duffy MJ, Rydén L, Gallagher WM, O’Brien SL.

Clin Cancer Res. 2006 Nov 1;12(21):6421-31.PMID: 17085655 [PubMed – indexed for MEDLINE]Free ArticleRelated citations

___________________________________________________________________________________________________________________________

Protein tyrosine phosphatases, new targets for cancer therapy.

Easty D, Gallagher W, Bennett DC.

Curr Cancer Drug Targets. 2006 Sep;6(6):519-32. Review.PMID: 17017875 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Molecular basis of cell-biomaterial interaction: insights gained from transcriptomic and proteomic studies.

Gallagher WM, Lynch I, Allen LT, Miller I, Penney SC, O’Connor DP, Pennington S, Keenan AK, Dawson KA.

Biomaterials. 2006 Dec;27(35):5871-82. Epub 2006 Aug 28.PMID: 16938344 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Novel method to prepare morphologically rich polymeric surfaces for biomedical applications via phase separation and arrest of microgel particles.

Lynch I, Miller I, Gallagher WM, Dawson KA.

J Phys Chem B. 2006 Aug 3;110(30):14581-9.PMID: 16869558 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Heteroaryl substituted titanocenes as potential anti-cancer drugs.

Sweeney N, Gallagher WM, Müller-Bunz H, Pampillón C, Strohfeldt K, Tacke M.

J Inorg Biochem. 2006 Sep;100(9):1479-86. Epub 2006 Apr 29.PMID: 16764931 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Proteomic analysis of factors released from p21-overexpressing tumour cells.

Currid CA, O’Connor DP, Chang BD, Gebus C, Harris N, Dawson KA, Dunn MJ, Pennington SR, Roninson IB, Gallagher WM.

Proteomics. 2006 Jul;6(13):3739-53. Erratum in: Proteomics. 2006 Jul;6(14):4203. PMID: 16739131 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

The development and validation of the Virtual Tissue Matrix, a software application that facilitates the review of tissue microarrays on line.

Conway CM, O’Shea D, O’Brien S, Lawler DK, Dodrill GD, O’Grady A, Barrett H, Gulmann C, O’Driscoll L, Gallagher WM, Kay EW, O’Shea DG.

BMC Bioinformatics. 2006 May 17;7:256.PMID: 16707006 [PubMed – indexed for MEDLINE]Free PMC ArticleFree textRelated citations

___________________________________________________________________________________________________________________________

TGF-beta1-induced thrombospondin-1 expression through the p38 MAPK pathway is abolished by fluvastatin in human coronary artery smooth muscle cells.

McGillicuddy FC, O’Toole D, Hickey JA, Gallagher WM, Dawson KA, Keenan AK.

Vascul Pharmacol. 2006 Jun;44(6):469-75. Epub 2006 Apr 19.PMID: 16624629 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Surface-induced changes in protein adsorption and implications for cellular phenotypic responses to surface interaction.

Allen LT, Tosetto M, Miller IS, O’Connor DP, Penney SC, Lynch I, Keenan AK, Pennington SR, Dawson KA, Gallagher WM.

Biomaterials. 2006 Jun;27(16):3096-108. Epub 2006 Feb 7.PMID: 16460797 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Supramolecular photonic therapeutic agents.

McDonnell SO, Hall MJ, Allen LT, Byrne A, Gallagher WM, O’Shea DF.

J Am Chem Soc. 2005 Nov 30;127(47):16360-1.PMID: 16305199 [PubMed – indexed for MEDLINE]Free ArticleRelated citations

___________________________________________________________________________________________________________________________

Low pH induces co-ordinate regulation of gene expression in oesophageal cells.

Duggan SP, Gallagher WM, Fox EJ, Abdel-Latif MM, Reynolds JV, Kelleher D.

Carcinogenesis. 2006 Feb;27(2):319-27. Epub 2005 Aug 19.PMID: 16113055 [PubMed – indexed for MEDLINE]Free ArticleRelated citations

___________________________________________________________________________________________________________________________

Application of DNA microarray technology in determining breast cancer prognosis and therapeutic response.

Brennan DJ, O’Brien SL, Fagan A, Culhane AC, Higgins DG, Duffy MJ, Gallagher WM.

Expert Opin Biol Ther. 2005 Aug;5(8):1069-83. Review.PMID: 16050784 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Fibulins and cancer: friend or foe?

Gallagher WM, Currid CA, Whelan LC.

Trends Mol Med. 2005 Jul;11(7):336-40. Review.PMID: 15961345 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Multiple markers for melanoma progression regulated by DNA methylation: insights from transcriptomic studies.

Gallagher WM, Bergin OE, Rafferty M, Kelly ZD, Nolan IM, Fox EJ, Culhane AC, McArdle L, Fraga MF, Hughes L, Currid CA, O’Mahony F, Byrne A, Murphy AA, Moss C, McDonnell S, Stallings RL, Plumb JA, Esteller M, Brown R, Dervan PA, Easty DJ.

Carcinogenesis. 2005 Nov;26(11):1856-67. Epub 2005 Jun 15.PMID: 15958521 [PubMed – indexed for MEDLINE]Free ArticleRelated citations

___________________________________________________________________________________________________________________________

Methoxy-phenyl substituted ansa-titanocenes as potential anti-cancer drugs derived from fulvenes and titanium dichloride.

Tacke M, Cuffe LP, Gallagher WM, Lou Y, Mendoza O, Müller-Bunz H, Rehmann FJ, Sweeney N.

J Inorg Biochem. 2004 Dec;98(12):1987-94.PMID: 15541486 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

In vitro demonstration of the heavy-atom effect for photodynamic therapy.

Gorman A, Killoran J, O’Shea C, Kenna T, Gallagher WM, O’Shea DF.

J Am Chem Soc. 2004 Sep 1;126(34):10619-31.PMID: 15327320 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Local drug delivery in restenosis injury: thermoresponsive co-polymers as potential drug delivery systems.

Kavanagh CA, Rochev YA, Gallagher WM, Dawson KA, Keenan AK.

Pharmacol Ther. 2004 Apr;102(1):1-15. Review.PMID: 15056495 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________

Fibulins: physiological and disease perspectives.

Argraves WS, Greene LM, Cooley MA, Gallagher WM.

EMBO Rep. 2003 Dec;4(12):1127-31. Review.PMID: 14647206 [PubMed – indexed for MEDLINE]Free PMC ArticleFree textRelated citations

___________________________________________________________________________________________________________________________

Interaction of soft condensed materials with living cells: phenotype/transcriptome correlations for the hydrophobic effect.

Allen LT, Fox EJ, Blute I, Kelly ZD, Rochev Y, Keenan AK, Dawson KA, Gallagher WM.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6331-6. Epub 2003 May 13.PMID: 12746496 [PubMed – indexed for MEDLINE]Free PMC ArticleFree textRelated citations

___________________________________________________________________________________________________________________________

Poly(N-isopropylacrylamide) co-polymer films as potential vehicles for delivery of an antimitotic agent to vascular smooth muscle cells.

Doorty KB, Golubeva TA, Gorelov AV, Rochev YA, Allen LT, Dawson KA, Gallagher WM, Keenan AK.

Cardiovasc Pathol. 2003 Mar-Apr;12(2):105-10.PMID: 12684168 [PubMed – indexed for MEDLINE]Related citations

___________________________________________________________________________________________________________________________