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Science Foundation Ireland for financial support

M2i for providing technical advice and discounted academic rates for FDG

We would like to thank the co-authors of the listed reference studies for their technical and other assistance.

Example Publications Taking Advantage of IVIS Spectrum, microCT and PET CT  at UCD:

1. Implementing subtype-specific pre-clinical models of breast cancer to study pre-treatment aspirin effects.

Miller IS, Khan S, Shiels LP, Das S, O’ Farrell AC, Connor K, Lafferty A, Moran B, Isella C, Loadman P, Conroy E, Cohrs S, Schibli R, Kerbel RS, Gallagher WM, Marangoni E, Bennett K, O’ Connor DP, Dwyer RM, Byrne AT.

Cancer Med. 2022 Oct;11(20):3820-3836. doi: 10.1002/cam4.4756. Epub 2022 Apr 17.

PMID: 35434898 Free PMC article.

2. Protocol for a preclinical systematic review and meta-analysis of pharmacological targeting of peroxisome proliferator-activated receptors in experimental renal injury.

Martin WP, Chuah YHD, Conroy E, Reynolds AL, Judge C, López-Hernández FJ, le Roux CW, Docherty NG.

BMJ Open Sci. 2021 Nov 15;5(1):e100240. doi: 10.1136/bmjos-2021-100240. eCollection 2021.

PMID: 34849404 Free PMC article.

3. Implementing Systems Modelling and Molecular Imaging to Predict the Efficacy of BCL-2 Inhibition in Colorectal Cancer Patient-Derived Xenograft Models.

O’Farrell AC, Jarzabek MA, Lindner AU, Carberry S, Conroy E, Miller IS, Connor K, Shiels L, Zanella ER, Lucantoni F, Lafferty A, White K, Meyer Villamandos MM, Dicker P, Gallagher WM, Keek SA, Sanduleanu S, Lambin P, Woodruff HC, Bertotti A, Trusolino L, Byrne AT, Prehn JHM.

Cancers (Basel). 2020 Oct 14;12(10):2978. doi: 10.3390/cancers12102978.

PMID: 33066609 Free PMC article.

4. The Molecular Effects of a High Fat Diet on Endometrial Tumour Biology.

Wilkinson M, Sinclair P, Dellatorre-Teixeira L, Swan P, Brennan E, Moran B, Wedekind D, Downey P, Sheahan K, Conroy E, Gallagher WM, Docherty N, Roux CL, Brennan DJ.

Life (Basel). 2020 Sep 10;10(9):188. doi: 10.3390/life10090188.

PMID: 32927694 Free PMC article.

5. An EPR Strategy for Bio-responsive Fluorescence Guided Surgery with Simulation of the Benefit for Imaging.

Daly HC, Conroy E, Todor M, Wu D, Gallagher WM, O’Shea DF.

Theranostics. 2020 Feb 10;10(7):3064-3082. doi: 10.7150/thno.42702. eCollection 2020.

PMID: 32194855 Free PMC article.

6. RGD conjugated cell uptake off to on responsive NIR-AZA fluorophores: applications toward intraoperative fluorescence guided surgery.

Wu D, Daly HC, Grossi M, Conroy E, Li B, Gallagher WM, Elmes R, O’Shea DF.

Chem Sci. 2019 Jun 21;10(29):6944-6956. doi: 10.1039/c9sc02197c. eCollection 2019 Aug 7.

PMID: 31588261 Free PMC article.

7. Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects.

Aviello G, Singh AK, O’Neill S, Conroy E, Gallagher W, D’Agostino G, Walker AW, Bourke B, Scholz D, Knaus UG.

Mucosal Immunol. 2019 Nov;12(6):1316-1326. doi: 10.1038/s41385-019-0205-x. Epub 2019 Sep 25.

PMID: 31554901

8. Durability of cell line xenograft resection models to interrogate tumor micro-environment targeting agents.

Miller IS, Shiels LP, Conroy E, Connor K, Dicker P, Gallagher WM, Donovan NO, Kerbel RS, Crown J, Byrne AT.

Sci Rep. 2019 Jun 24;9(1):9204. doi: 10.1038/s41598-019-45444-0.

PMID: 31235775 Free PMC article.

9. 1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours.

Butler CT, Kennedy SA, Buckley A, Doyle R, Conroy E, Gallagher WM, O’Sullivan J, Kennedy BN.

Oncotarget. 2019 Jun 4;10(38):3725-3744. doi: 10.18632/oncotarget.26966. eCollection 2019 Jun 4.

PMID: 31217905 Free PMC article.

10. Imaging Intestinal ROS in Homeostatic Conditions Using L-012.

Conroy E, Aviello G.

Methods Mol Biol. 2019;1982:313-327. doi: 10.1007/978-1-4939-9424-3_19.

PMID: 31172481

11. Correction: BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer.

Shields S, Conroy E, O’Grady T, McGoldrick A, Connor K, Ward MP, Useckaite Z, Dempsey E, Reilly R, Fan Y, Chubb A, Matallanas DG, Kay EW, O’Connor D, McCann A, Gallagher WM, Coppinger JA.

Oncotarget. 2019 May 3;10(33):3144. doi: 10.18632/oncotarget.26920. eCollection 2019 May 3.

PMID: 31139326 Free PMC article.

12. PEGylated BF2-Azadipyrromethene (NIR-AZA) fluorophores, for intraoperative imaging.

Wu D, Daly HC, Conroy E, Li B, Gallagher WM, Cahill RA, O’Shea DF.

Eur J Med Chem. 2019 Jan 1;161:343-353. doi: 10.1016/j.ejmech.2018.10.046. Epub 2018 Oct 19.

PMID: 30368132

13. BAG3 promotes tumour cell proliferation by regulating EGFR signal transduction pathways in triple negative breast cancer.

Shields S, Conroy E, O’Grady T, McGoldrick A, Connor K, Ward MP, Useckaite Z, Dempsey E, Reilly R, Fan Y, Chubb A, Matallanas DG, Kay EW, O’Connor D, McCann A, Gallagher WM, Coppinger JA.

Oncotarget. 2018 Feb 28;9(21):15673-15690. doi: 10.18632/oncotarget.24590. eCollection 2018 Mar 20.

PMID: 29644001 Free PMC article.

14. Therapeutic Rationale to Target Highly Expressed CDK7 Conferring Poor Outcomes in Triple-Negative Breast Cancer.

Li B, Ni Chonghaile T, Fan Y, Madden SF, Klinger R, O’Connor AE, Walsh L, O’Hurley G, Mallya Udupi G, Joseph J, Tarrant F, Conroy E, Gaber A, Chin SF, Bardwell HA, Provenzano E, Crown J, Dubois T, Linn S, Jirstrom K, Caldas C, O’Connor DP, Gallagher WM.

Cancer Res. 2017 Jul 15;77(14):3834-3845. doi: 10.1158/0008-5472.CAN-16-2546. Epub 2017 Apr 28.

PMID: 28455421

15. A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate.

O’Farrell AC, Evans R, Silvola JM, Miller IS, Conroy E, Hector S, Cary M, Murray DW, Jarzabek MA, Maratha A, Alamanou M, Udupi GM, Shiels L, Pallaud C, Saraste A, Liljenbäck H, Jauhiainen M, Oikonen V, Ducret A, Cutler P, McAuliffe FM, Rousseau JA, Lecomte R, Gascon S, Arany Z, Ky B, Force T, Knuuti J, Gallagher WM, Roivainen A, Byrne AT.

PLoS One. 2017 Jan 27;12(1):e0169964. doi: 10.1371/journal.pone.0169964. eCollection 2017.

PMID: 28129334 Free PMC article.

16. Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer.

Murphy AG, Casey R, Maguire A, Tosetto M, Butler CT, Conroy E, Reynolds AL, Sheahan K, O’Donoghue D, Gallagher WM, Fennelly D, Kennedy BN, O’Sullivan J.

Sci Rep. 2016 Oct 14;6:34523. doi: 10.1038/srep34523.

PMID: 27739445 Free PMC article.

17. Lysosome triggered near-infrared fluorescence imaging of cellular trafficking processes in real time.

Grossi M, Morgunova M, Cheung S, Scholz D, Conroy E, Terrile M, Panarella A, Simpson JC, Gallagher WM, O’Shea DF.

Nat Commun. 2016 Mar 1;7:10855. doi: 10.1038/ncomms10855.

PMID: 26927507 Free PMC article.

18. Patterns of orofacial clefting in the facial morphology of bats: a possible naturally occurring model of cleft palate.

Orr DJ, Teeling EC, Puechmaille SJ, Finarelli JA.

J Anat. 2016 Nov;229(5):657-672. doi: 10.1111/joa.12510.

PMID: 27346883

19. Small field detector correction factors kQclin,Qmsr (fclin,fmsr) for silicon-diode and diamond detectors with circular 6 MV fields derived using both empirical and numerical methods.

O’Brien DJ, León-Vintró L, McClean B.

Med Phys. 2016 Jan;43(1):411. doi: 10.1118/1.4938584.

PMID: 26745934