Skip to content

microCT

microCT

MicroCT allows longitudinal non invasive 3-d imaging of animals or objects with a high spatial resolution based on the differential attenuation of X-rays. X-ray tube and detector rotate around subject or item to be imaged and projections are reconstructed into 3-d images.  Imaging protocol can be optimized for low dose, high resolution, high throughput, low noise, soft or hard material etc. depending on requirements.

Link to sample studies using SPECT

What Can Be Scanned?

Some examples:

  • Live animals housed in the Biomedical Facility (BMF)
    • Soft tissue protocol enhanced by contrast agent
    • Density and architectural changes in bone
    • Cardiac and respiratory gating is possible for lung and heart imaging
  • Inanimate Objects
    • Plants, insects etc.
    • Bone, fossils
    • Materials of various textures and materials

Please note:

Any object being brought into BMF for CT imaging must be approved for entry by the Biomedical Facility Director.  This is to prevent any unwanted entry of pathogens.

In general they will be approved if:

  • Items can be sprayed down with a water based disinfectant
  • Items can undergo VHP (vapourised hydrogen peroxide decontamination)
  • Alternatively items can be placed in a sealed plastic container that will not significantly attenuate X-rays or cause artifacts.  The outside of the container can be decontaminated and object to be imaged must not be removed from container while inside the BMF.
  • Animals will only be imaged provided the relevant Department of Health licence and internal AREC approvals have been granted.

Instrumentation

CT120

The CT120 is integrated with the Explore SpecZT scanner provides high-resolution images (typically 80 microns), rapid data acquisition, excellent sensitivity to skeletal tissue and sensitivity to soft tissue, particularly when contrast-enhancing media are employed. Cardiac and respiration gating are possible.

Specification:

  • 85 mm trans-axial diameter
  • 55 mm axial length per rotation (scans can be merged to give a total length of 275 mm)
  • Physical image resolution = 80 µm FWHM
  • Acquired Pixel sizes of 25 µm, 50 µm and 100 µm
  • 70 to 120 kV potential, specified by user

CT XO

CT XO integrated with PET Triumph computed tomography is a means for detecting and characterizing soft-tissue structures, skeletal abnormalities, and tumors in live animals.  The CT integrated with the PET scanner provides high-resolution images (typically 150 microns), rapid data acquisition, excellent sensitivity to skeletal tissue and good sensitivity to soft tissue, particularly when contrast-enhancing media are employed.  If cardiac and respiration gating are necessary please read about our CT120.

Specification:

  • 97 mm trans-axial diameter
  • 93 mm axial length
  • Physical image resolution = 50-180 µm FWHM
  • Acquired Pixel sizes of 60-180 µm
  • 40-80 kV potential, specified by user
  • Zoom feature for acquiring a large field of view or high resolution

Data Analysis and Image Viewing Software

All software is available on work stations in the BMF and on a dedicated imaging analysis computer in the Conway Institute area reading area 6.

CT_XO_4.2.0.0

  • CT Imaging
  • Reconstruction

PC-Sam

  • Vital Signs monitoring; temperature, ECG & respiration

PMOD

  • General Viewing and Imaging Processing Tool (PBAS)
  • VOI Definition
  • VOI Operations

Microview (incl. Advance Bone Analysis option)

MicroView is a visualization and quantification tool for 2-dimensional and 3-dimensional data. It complements GE Healthcare’ MicroCT systems by offering a number of visualisation and analysis tools for MicroCT data

Amide 0.9.1

AMIDE is a completely free tool for viewing, analyzing, and registering volumetric medical imaging data sets.